Details:

Synthetic Organic Chemistry Quinine CAS 130-95-0 Pharmaceuticals

Product Name: Quinine
Synonyms: (8-alpha,9r)-6’-methoxycinchonan-9-ol;(8S,9R)-6'-Methoxycinchonan-9-ol;(8S,9R)-Quinine;6’-methoxy-,(8.alpha.,9R)-Cinchonan-9-ol;6’-methoxy-,(8-alpha,9r)-cinchonan-9-o;(6-METHOXY-4-QUINOLYL)(5-VINYL-1-AZABICYCLO[2.2.2]OCT-2-YL)METHANOL;6-METHOXYCINCHONINE;A-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINE-METHANOL
CAS: 130-95-0
MF: C20H24N2O2
MW: 324.42
EINECS: 205-003-2

Quinine Chemical Properties
Melting point 173-175 °C(lit.)
alpha -172 º (c=1, EtOH)
storage temp. Refrigerator
solubility H2O: soluble
form Crystalline Powder
pka 8.52(at 25℃)
color White
PH Range Blue I uorescence (3.0) to weak violet I uorescence (5.0);Weak violet I uorescence (9.5) to nonI uorescence (10.0)
PH 9.0 (0.5g/l, H2O, 20℃)
Water Solubility slightly soluble
Sensitive Light Sensitive
Merck 14,8061

Uses Quinine is one of the oldest antimalarial drugs. At as early as the 15th century, the quinine-containing cinchona bark has been used extensively in the treatment of malaria with its antimalarial effect being similar to that of chloroquine that is through interfering with DNA synthesis effect. It is capable of inhibiting the erythrocytic stage of a variety of Plasmodium, being able to control the malaria symptoms. It also has certain killing effect on the gametes of vivax malaria and quartan malaria. However, it has no effect on the exoerythrocytic stage. Its major advantage is not easy to produce drug resistance, possibly due to that quinine binds the plasmodium DNA in a different way from chloroquine, so having no cross-resistance and can be used for the treatment of the infection of anti-chloroquine strains (especially Plasmodium falciparum). In addition, quinine can also exciting the uterus, inhibit the myocardium and have antipyretic analgesic effect. In addition to medicinal application, in analytical chemistry it can be used as the detection agent of bismuth, platinum and other metal ions and also be used for the separation agent of racemic organic acid.

Chemical Properties white to light yellow crystal powde
Uses Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal)
Uses Because of its relatively constant and well-known fluorescence quantum yield, quinine is also used in photochemistry as a common fluorescence standard. It has been used for imaging of oxygen evolution and oxide formation. Chloride and bromide have been sh
Uses antimalarial, skeletal muscle relaxant