99% Isotretinoin Ma...

99% Isotretinoin Manufacturer 4759-48-2 For Treat Hemorrhoids

99% Isotretinoin Manufacturer 4759-48-2 For Treat Hemorrhoids

Min.Order / FOB Price:Get Latest Price

10 Gram

Negotiable

  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : T/T,

Keywords

99%min Isotretinoin Isotretinoin Manufacturer For Treat Hemorrhoids

Quick Details

  • Appearance:White Powder
  • Application: It Can Be Used As Pharmaceutical Intermediates, Or As Curing Agent Of Epoxy Resins, Etc
  • PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
  • ProductionCapacity:10000|Metric Ton|Month
  • Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
  • Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

Superiority:

 

Advantages:
 
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

 

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

Details:

Isotretinoin Basic information
Pharmacological effects Physical and Chemical Properties Pharmacokinetics Indications Clinical application Toxicity Drug Interactions Contraindications Side effects Chemical Properties Uses Production methods
Product Name: Isotretinoin
Synonyms: RETINOIC ACID, 13-CIS-;3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid;3,7-DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-2Z,4E,6E,8E-NONATETRANENOIC ACID;13-CIS-RETINOIC ACID;13-cis-vitamin a acid;(L)-ISOTRETINOIN;ISOTRETINOIN;Lsotretinoin
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Product Categories: Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;-;API;BUSPAR;Other APIs;intermediates
Mol File: 4759-48-2.mol
Isotretinoin Structure
 
Isotretinoin Chemical Properties
Melting point  172-175 °C(lit.)
Boiling point  381.66°C (rough estimate)
density  1.0597 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  −20°C
solubility  Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). It is sensitive to air, heat and light, especially in solution. Carry out all operations as rapidly as possible and avoid exposure to actinic light; use freshly prepared solutions.
form  Fine Crystalline Powder
color  Yellow-orange to orange
Water Solubility  insoluble
λmax 354nm(EtOH)(lit.)
Merck  14,5228
Stability: Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference 4759-48-2(CAS DataBase Reference)
EPA Substance Registry System Retinoic acid, 13-cis-(4759-48-2)
 
Safety Information
Hazard Codes  T
Risk Statements  61-36/37/38-20/21/22
Safety Statements  53-26-36/37/39-45-37/39
WGK Germany  3
RTECS  VH6440000
TSCA  Yes
HS Code  29362100
Hazardous Substances Data 4759-48-2(Hazardous Substances Data)
Toxicity LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm)
Uses Vitamin A class drugs. It can rapidly and strongly inhibit the cell proliferation and differentiation process of skin glands cells. It has a high effect on severe nodular cystic acne. This product has a high gastrointestinal absorption, but invalid for topical administration. It is used for treating severe acnes which cannot be treated by other drugs. It also has some effects on treating cystic acne, the party of acne, rosacea, ichthyosis, follicular keratosis and pityriasis red hair and other skin diseases.
Production methods β-ionone and ethyl chloride are first reacted together after which the product is further reacted with triphenylphosphine to obtain Triphenyl salt. The Triphenyl salt is further reacted with cyclopentenone derivative to produce isotretinoin and its 8Z isomer. 
Separate out the 8Z isomer and convert it to isotretinoin through isomerization with the help of nitric acid.
Chemical Properties Yellow-Orange Crystalline Powder
Uses 5HT1a receptor agonist, anxiolytic
Uses isotretinoin is a retinoid derivative with improved bioavailability and percutaneous absorption for acne treatment products.
Uses Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.

 

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