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Liraglutide 204656-20-2 Liraglutidum
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This product is used to control blood glucose in adult patients with type 2 diabetes:
For patients with poor glycemic control after maximum tolerable dose of metformin or sulfonylureas alone, in combination with metformin or sulfonylureas.
Liraglutide has the following pharmacological effects:
Protective effect on islet β cells
The effect of reducing body mass
Effects of liraglutide on cardiovascular function
Protective effect on the liver
Therapeutic effect on Alzheimer's disease (AD)
Liraglutide is a clear, colorless solution. The dosage form is subcutaneous injection. Liranlutide has been developed for more than 10 years to promote islet cell regeneration, lower blood sugar, reduce weight and protect the cardiovascular system. It is marketed as Victoza for type 2 diabetes and Saxenda for chronic obesity as a supplement to diet and physical activity. Liraglutide is an acylated human glucagon-like peptide-1 (GLP-1) receptor agonist, which is 97% homologous with human endogenous Gchemical bookLP-1 (7-37) amino acid sequence, retains all the biological activities of GLP-1, and has GLP-1 receptor agonist effect. Through the expression of recombinant DNA in S. cerevisiae, the molecular structure of the recombinant DNA was only one amino acid different from that of natural GLP-1. Only two parts of GLP-1 were modified as follows: lysine 34 was replaced by arginine, and a glutamate-mediated 16-carbon palmitoyl fatty acid side chain was added to lysine 26.
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