Triptorelin D-TRP6 GNRH
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Triptorelin description
Triptorelin is a decapeptide (Sequence is pglu-his-trp-ser-tyr-d-trp-leu-arg-pro-gly-nh2). The active
ingredient of triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) analogue, which is
also known as decapeptyl, diphereline, triptorelin acetate, gonadorelin. It is an antineoplastic drug,
whose pharmacological effects are same with goserelin, buserelin, and its structure is modified by
natural molecular structure of the sixth L-glycine that is replaced by D-tryptophan to promote
efficiency and prolong the plasmic half-life time, as well as enhance drug efficacy.
Triptorelin Specification
Items | Specifications | Results |
Appearance | White powder | Conforms |
Purity(HPLC) | ≥98% | 98.98 |
Single Impurity (HPLC) | ≤2.0% | Conforms |
Peptide Content (N%) | ≥80.0% | 86.10% |
Water Content (Karl Fischer) | ≤8.0% | 6.50% |
Acetate Content (HPIC) | ≤12.0% | 6.60% |
Mass Balance | 95.0~105.0% | Conforms |
Test date | 2018/11/12 |
Applications
It Clinically, it uses for the treatment of endometriosis, hormone-dependent prostate cancer,
breast cancer, precocious puberty, as well as it may also be used as assisted reproductive
technology.
Storage
Cool dry place
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