Cytisine mono-Ethyl succinate ALDRICH
Cytisine was found to be more effective than nicotine-replacement therapy in helping smokers to quit smoking. It is an ?4 ?2 nicotinic receptor partial agonist. It is a plant alkaloid which is commercially extracted for use as a smoking cessation medication. Preparation of nicotine partial agonist cytisine via "in situ" Stille or Suzuki biaryl pyridine coupling has been reported. Cytisine is a competitive partial agonist at ?4 subunit-containing nicotinic acetylcholine (nACh) receptors while at homomeric ?7-nACh receptors it behaves as a full agonist with a relatively lower potency.
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