SDA (NHS-Diazirine) (succinimidyl 4,4'-azipentanoate)

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SDA (NHS-Diazirine) (succinimidyl 4,4'-azipentanoate) Dimethylphenylvinylsilane ALDRICH

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Succinimidyl-diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions, and these SDA reagents extend the efficiency and range of interactions that can be explored by this approach.

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