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100 Gram |
Negotiable |
50-18-0 Cyclophosphamide C7H15Cl2N2O2P
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Specification: 99%
CAS NO.:50-18-0
Appearance: white crystalline powder
Molecular weight: 261.09
This product in vitro no anti-tumor activity, into the body after the first in the liver by the microbial function of oxidase into aldophosphamide. And amide is unstable, in the tumor cells into amide mustard and acrolein, amide mustard cytotoxic effect on tumor cells. Cyclophosphamide is a bifunctional alkylating agent and cell cycle non-specific drugs, can interfere with DNA and RNA function, especially in the former greater impact, it is cross-linked with DNA, inhibit DNA synthesis, the most obvious role in the S phase.
The product is the most commonly used alkylating agent antineoplastic drugs, into the body, the liver microsomal enzyme decomposition of the decomposition of the release of a strong alkylation of chloroethyl phosphate (or phosphoramide nitrogen mustard), and Tumor cells produce cytotoxic effect, in addition to this product also has significant immunosuppressive effect.
Clinical for malignant lymphoma, multiple myeloma, leukemia, breast cancer, ovarian cancer, cervical cancer, prostate cancer, colon cancer, bronchial cancer, lung cancer, have a certain effect. Can also be used for rheumatoid arthritis, nephrotic syndrome in children and the treatment of autoimmune diseases.
Broad spectrum Antitumor drugs used to treat leukemia and other cancers
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