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1 Gram |
Negotiable |
BA 058 BIM 44058 (Aib29)- Semparatide
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Name:Abaloparatide
Cas No: 247062-33-5
Formula: C174H300N56O49
Molecular:3960.6
Sequence: Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2
Function
1.Osteoporosis
Application Research
Abaloparatide has shown to induce higher incidences of osteosarcoma in a dose-dependent manner in a 2 year carcinogenicity study with female and male rats. This correlation is not known to be reflected in humans, however patients with increased risk of osteosarcoma including Paget's disease, open epiphyses, and skeletal malignancies should avoid this treatment. Abaloparatide may also cause hypercalcemia so should be avoided in patients with pre-existing conditions of primary hyperthyroidism or hypercalcemia. Overdose is commonly associated with hypercalcemia, nausea, vomiting, dizziness, tachycardia, orthostatic hypotension and headache. There is no known antidote for abaloparatide.
Specifications
Purity (HPLC) |
98% min. |
Appearance |
White powder |
Single Impurity(HPLC) |
1.0%max |
Amino Acid Composition |
±10% of theoretical |
Peptide Content(N%) |
≥80.0% |
Water Content(Karl Fischer) |
≤8.0% |
Acetate Content(HPIC) |
≤12.0% |
Specific Rotation (20/D) |
-37.0~-47.0°(c=1 1%HAc) |
MS(ESI) |
Consistent |
Mass Balance |
95.0~105.0% |
Remarks: The products are restricted in lab research only.
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