2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl

2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl

Min.Order / FOB Price:Get Latest Price

20 Gram	FOB Price:USD 245.0000 -280.0000

20 Gram

FOB Price:USD 245.0000 -280.0000

Min.Order :20 Gram
Purity: ≥99%
Payment Terms : L/C,T/T

Keywords

284461-73-0 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl Sorafenib

Quick Details

Appearance:white powder
Application:food pharma
PackAge:as per client's requirement
ProductionCapacity:1000|Kilogram|Month
Storage:in cool, dry place
Transportation:Cool dry place, away from the light;

Superiority:

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2. years produce and exporting experience

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3. quick response for all inquiries or claims

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Details:

Product name:sorafenib

synonyms:bay43-9006;n-[4-chloro-3-(trifluoromethyl)phenyl]-n'-[4-[2-(n-methylcarbamoyl)-4-pyridyloxy]phenyl]urea

specification: 98%

cas no.:284461-73-0

appearance: white crystalline powder

molecular weight: 464.82

molecular formula:c21h16clf3n4o3

items	specifications	results
appearance	off white powder to white powder	off-white powder
identification	h-nmr, ms	complies
water content	< 0.5%	0.06%
loss on drying	<1.0%	0.02%
related impurity by hplc	total impurity ≤1.0% single impurity≤0.3%	0.05% 0.04%
purity (hplc)	≥99%	99.95%

function and application:

sorafenib is a raf kinase inhibitor which suppresses erk phosphorylation. studies indicate that sorafenib induces c-raf phosphorylation

$zhanwei$

at both ser-43 and ser-259. when combined with vitamin k1 phosphorylation is increased at these serine residues. sorafenib also induces the phosphorylation of pka. in addition, sorafenib induces c-met phosphorylation at tyr-1349, which consequently induces pi3k-akt phosphorylation. studies determined that sorafenib inhibits other kinases such as flk-1 (vegfr2), platelet-derived growth factor receptor (pdgfr), flt3, ret, and c-kit.

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