CAS 1405-20-5 Polymyxin B Sulphate Pharmaceutal USP Grade White Powder
Product Description
1. Quick Detail:
CAS: 1405-20-5
Quality: EP/USP
Appearance: White to alomost white powder, hygroscopic
Certificates: ISO/DMF
2. Description:
Polymyxin B sulfate/trimethoprim is an antibiotic eye drop composed of two drugs. Polymyxin B sulfate works by altering bacterial cell wall structure that causes the leaking out of cellular contents that can result in cell death. Trimethoprim is an antibiotic that interferes with the production of tetrahydrofolic acid, a chemical that is necessary for bacteria and human cells to produce proteins. Trimethoprim inhibits production of tetrahydrofolic acid by inhibiting the enzyme responsible for making tetrahydrofolic acid from dihydrofolic acid. This inhibition interferes with the ability of bacteria to survive. Polymyxin B sulfate/trimethoprim is effective against gram-positive and gram-negative bacteria such as Staphylococcus aureus and epidermis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumonia, E. coli, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The FDA approved polymyxin B sulphate/trimethoprim in October 1988.
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3. Specification:
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SPECIFICATION of Polymyxin B Sulphate |
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DESCRIPTION |
WHITE TO ALMOST WHITE POWDER,HYGROSCOPIC. |
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SOLUBILITY |
FREELY SOLUBLE IN WATER;SLIGHTLY SOLUBLE IN ALCOHOL. |
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IDENTIFICATION |
A. LIQUID CHROMATOGRAPHIC IDENTIFICATION TEST |
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PH(2%) |
5.0~7.0 |
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PH(0.5%) |
5.0~7.5 |
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SPECIFIC ROTATION |
-78°- -90° |
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LOSS ON DRYING |
NOT MORE THAN 7.0% |
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PHENYLALANINE |
9.0%~12.0% |
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SULPHATED ASH |
NOT MORE THAN 0.75% |
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SULPHATE |
15.5%~17.5% |
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HEAVY METALS |
NOT MORE THAN 20PPM |
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ASSAY(MICROBIAL) |
NOT LESS THAN 6500IU/MG |
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PARTICLE SIZE |
99.0%:NOT MORE THAN 30um BY VOL. |
4. Applications:
This medication is used to treat bacterial infections (such as blepharitis, conjunctivitis) of the eye. It contains 2 antibiotics. Polymyxin B works by killing the bacteria.Trimethoprim works by stopping the growth of the bacteria.
This medication treats only bacterial eye infections. It will not work for other types ofeye infections. Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
Advantages:
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