DNA-Encoded Fragment Library - DyNAbind

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DNA-encoded library Fragment Library drug discovery

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Application:DNA-encoded library (DEL) technology is a drug discovery tool containing small DNA-barcoded compounds (Satz 2018). The DyNAbind fragment DEL contains small molecular weight compounds. The high ligand
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DNA-encoded library (DEL) technology is a drug discovery tool containing small DNA-barcoded compounds (Satz 2018). The DyNAbind fragment DEL contains small molecular weight compounds. The high ligand efficiency of fragment molecules is harnessed to effectively probe a target′s binding site and increase the likelihood of discovering binders (Murray and Rees 2009, Murray et al. 2012). Moreover, this library uses DyNAbind′s proprietary Dynamic Library technology to drive binder optimization and reveal not only individual fragments, but also joined fragment pairs for over 370,000 highly diverse structures (Reddavide et al. 2015). DyNAbind′s proprietary Dynamic Library technology reshuffles fragment pairs to automatically optimize the affinity of binders and increase the chances of finding good hits. After a pooled screening approach, bound fragments can be determined using next-generation sequencing of the barcodes. Analysis of the sequencing data is provided at no additional cost through a portal on our website which will generate a list of the fragments that bind the target. These fragments can be used as structural starting points to develop larger, more drug-like compounds. Analysis Portal: SigmaAldrich.com/DELanalysis

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Product Features and Benefits:

• Off-the-shelf, affordable access to DEL technology
• Dynamic fragment library provides a revolutionary approach to DELs offering unprecedented library and data quality
• High level quality control with every single member individually purified and validated to maximize data reliability and chances for finding good hits
• Rule of Three used in library design ensures compounds are in favorable fragment space with good ligand efficiency and plenty of room for optimization (Congreve et al. 2003, Jhoti et al. 2013)
• Ability to perform and validate initial DEL screening internally before engaging service provider
• A library with maximized diversity, ready to deploy against nearly any druggable target

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DyNAbind is a registered trademark of DyNAbind GmbH

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