Adrenoreceptor Blocker Dexpropranolol Propranolo /Dexpropranolol HCl CAS 318-98-9
Quick Details:
Product Name:propranolo hydrochloride
Synonyms:(RS)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE;PROPRANOLO HCL;(+/-)-PROPRANOLO HYDROCHLORIDE;PROPRANOLO HYDROCHLORIDE;(+/-)-PROPANOLOL HCL;PROPANOLOL HYDROCHLORIDE;1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanohydrochloride;1-(1-naphthyloxy)-2-hydroxy-3-isopropylaminopropanehydrochloride
CAS:318-98-9
MF:C16H22ClNO2
MW:295.8
EINECS:206-268-7
Product Categories:Aromatic alcohols and diols;Intermediates & Fine Chemicals;Pharmaceuticals;API's;APIs;Amines;Aromatics;Pharmaceutical intermediate;INDERAL
Melting point:163-165 °C(lit.)
Fp:9ºC
storage temp.:2-8°C
solubility:H2O: 50 mg/mL, clear, colorless
Chemical Properties:Off-White to Light-Yellow Cyrstalline Solid
Uses:Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
Uses:For the prophylaxis of migraine
Descripiton:
propranolo is a nonselective beta-adrenergic receptor blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta-adrenergic receptor stimulating agents for available receptor sites. When access to beta-receptor sites is blocked by propranolo, chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportionately.
Use:
This medication is a beta blocker used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions. It is used after a heart attack to improve the chance of survival. It is also used to prevent migraine headaches and chest pain (angina). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Preventing chest pain can help improve your ability to exercise.
This drug works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This effect reduces heart rate, blood pressure, and strain on the heart.
What is Propranol hydrochloride
Propranol hydrochloride is an oral drug that can reduce the burden on your heart and help it beat it more effectively. It is used to treat high blood pressure, control rhythm, relieve chest pain, prevent migraine, reduce tremor or tremor, and help thyroid and adrenal gland conditions.
The drug has a different dosage form, including oral tablets, extended release capsules and liquid solutions.
Your dose depends on the form of the drug you are taking, the condition being treated, your age and your response to the drug. Your doctor will decide to fit your dose.
Common side effects include sexual behavior or performance changes, diarrhea, dry eyes, hair loss, nausea, fatigue or fatigue.
Do not stop taking this medicine unless your doctor tells you. Sudden cessation of propranolo can worsen your heart disease, especially if you have heart disease. If necessary, your doctor will tell you how to safely stop.
Important information of Propranol hydrochloride:
Stop the treatment of the warning: Do not stop taking this drug, and do not tell the doctor first. The cessation of propranolo may suddenly lead to changes in rhythm and blood pressure, increased chest pain or heart attack. Your doctor will slowly reduce the dose in a few weeks to prevent these effects.
Drowsiness Warning: This medicine can cause drowsiness. Do not drive, operate the machine, or do anything you need to be vigilant until you know how the drug affects you.
Diabetes warns: propranolo can cause hypoglycemia (hypoglycemia). It may also mask signs of hypoglycemia, such as higher than normal heart rate, sweating and tremor. If you are suffering from diabetes, please use this medicine with particular care, especially if you are taking insulin or other diabetes that can cause hypoglycemia. This drug may also cause low blood sugar in infants, children and adults without diabetes. It is more likely to have a long time or a kidney problem.
Asthma Warning: Do not take propranolo if you have asthma or similar breathing problems. It can make your asthma worse.
Drug characteristics:
Propranolo hydrochloride is provided in a generic form. Common drugs are usually less expensive. In some cases, they may not be in every strength or form of the brand. Contact your health care provider to see if the generic product is available for you.
The drug can be used to control blood pressure or other drugs that reduce the symptoms of adrenal tumors.
Why use Propranol hydrochloride
Propranolo hydrochloride reduces the workload of the heart and helps it beat more often. It is used to treat high blood pressure, control rhythm, relieve chest pain (caused by angina), prevent migraine, reduce tremor or tremor, and help your thyroid and adrenal gland medical conditions. If heart attack, propranolo may also be helpful.
How to run Propranol hydrochloride
Propranolo hydrochloride belongs to a class of drugs called beta-blockers. A class of drugs refers to a similar drug. They have similar chemical structures and are commonly used to handle similar conditions.
Propranolo is a nonselective beta receptor blocker. This means that it is similar in the heart, lungs and other areas of the body.
It is not clear how this medicine is used to lower blood pressure. It reduces the workload of the heart and prevents the release of substances called renin from the kidneys.
Β blockade helps to control the rhythm, delay the onset of chest pain, prevent migraine, reduce tremor. It is not yet fully understood how the drug deals with these problems.
COA:
Items |
Specifications |
Results |
Appearance |
A white or almost white powder |
Conforms |
Solubility |
Soluble in water and in ethanol (96%) |
Conforms |
Identification |
|
|
A |
Melting point : 163°C~166°C |
164.0~164.5°C |
B |
Examine by infrared absorption spectrophotometry, comparing with the spectrum obtained with propranolo hydrochloride CRS. |
Conforms |
C |
Examine by thin-layer chromatography. The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution. |
Conforms |
D |
It gives reaction(a) of chlorides |
Conforms |
Tests |
|
|
Appearance of solution |
The solution is clear and not more intensely coloured than intensity 6 of the range of reference solutions of the most appropriate colour |
Conforms |
Acidity or alkalinity |
Add 0.1ml of methyl red solution R and 0.2 ml of 0.01M hydrochloric acid, the solution is red. Add 0.4ml of 0.01 M sodium hydroxide. The solution is yellow. |
Conforms |
Related substances |
Any impurity NMT 0.1% |
0.03% |
|
The sum of all impurities NMT 0.4% |
0.21% |
Heavy metals |
NMT 20ppm |
Conforms |
Loss on drying |
NMT 0.5% |
0.11% |
Sulphated ash |
NMT 0.1% |
0.08% |
Residual solvents |
A: ethanol: NMT 5000ppm |
Conforms |
Assay |
99.0%~101.0% |
99.3% |
Conclusion: conform to EP7.0 |