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Details:

Cyproheptadine hydrochloride cas 41354-29-4

CAS No.: 41354-29-4

EINECS No.: 213-535-1

Molecular Formula: C21H22ClN

Molecular Weight: 323.86

Melting point: 165 °C (dec.)(lit.)

Appearance: white to light yellow crystalline powder

Standard: Enterprise Standard

Indication

For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine  

Main function:

Cyproheptadine is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Cyproheptadine useful in conditions such as vascular headache and anorexia. Cyproheptadine does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Cyproheptadine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Cyproheptadine exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Cyproheptadine's antiemetic effects, although the exact mechanism is unknown. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite. Cyproheptadine also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Cyproheptadine exerts a beneficial effect on this condition.

Cyproheptadine hydrochloride

Cyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.

Cyproheptadine is used to treat allergic reactions (specifically hay fever).

Has shown effectiveness in the treatment of nightmares including nightmares related to post traumatic stress disorder.

Has been used in the management of moderate to severe cases of serotonin syndrome (a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of hyperserotoninaemia resulting from a serotonin producing carcinoid tumour

Can also be used as a preventive measure against migraine in children and adolescents.

Can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating).

Also used in the treatment of cyclical vomiting syndrome and to stimulate the appetite.

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