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Atosiban 90779-69-4 90779-69-4 Atosiban
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Atosiban Basic information |
Product Name: | Atosiban |
Synonyms: | 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin;oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l;Atosiban Impurtiy;rwj22164;ATOSIBAN ACETATE;1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin;[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2;(2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
CAS: | 90779-69-4 |
MF: | C45H71N11O14S2 |
MW: | 994.19 |
EINECS: | 806-815-5 |
Product Categories: | Peptide;hormones |
Mol File: | 90779-69-4.mol |
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Atosiban Chemical Properties |
storage temp. | −20°C |
solubility | H2O: ≤100 mg/mL |
form | solid |
CAS DataBase Reference | 90779-69-4(CAS DataBase Reference) |
Safety Information |
WGK Germany | 3 |
RTECS | RS7590000 |
Atosiban Usage And Synthesis |
Description | Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively. |
Originator | Ferring AB (Sweden) |
Uses | Premature labor |
Uses | Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency. |
Brand name | Tractocile, Antocin |
Anticancer Research | The antitumor effects of the essential oil of O. falcata were tested in transplantedmurine H22 solid tumors in vivo. Growth inhibition in H22 solid tumors was moderate(Yang et al. 2013). |
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