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9041-93-4 Bleomycin sulfate Antibiotic
Bleomycin sulfate is one kind of white powder. It is soluble in water, methanol, slightly soluble in ethanol, practically insoluble in acetone, ethyl acetate, butyl acetate, ethyl ether.
Bleomycin sulfate is the sulfate salt of a complex natural product antibiotic. This compound approximates metals such as Fe(II) which then coordinate dioxygen to generate the active species. This Bleomycin-metal-dioxygen species is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis. The species also degrades RNA, and has been reported to display selectivity for RNA over DNA.
CAS: 9041-93-4
Product Name: Bleomycin sulfate
Synonyms: Blenmycins;bleomycin,sulfate(salt);NSC-125066;BLEOMYCIN SULFATE;BLEOMYCIN SULPHATE;BLEOMYCIN SULFATE, STREPTOMYCES VERTICILLUS;BLEXANE;BLEO
MF: C110H168N34O46S7
MW: 2927.17
EINECS: 232-925-2
Product Categories: Active Pharmaceutical Ingredients;UVCBs-biological;Intermediates & Fine Chemicals;Pharmaceuticals;Carbohydrates & Derivatives;Sulfur & Selenium Compounds
Mol File: 9041-93-4.mol
Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. Bleomycin refers to a family of structurally related compounds.When used as an anticancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2. The drug is used in the treatment of Hodgkin's lymphoma
(as a component of the ABVD and BEACOPP regimen), squamous cell carcinomas,and testicular cancer, as well as in the treatment of plantar warts and asa means of effecting pleurodesis.The mechanism of action involves breaking DNA.Bleomycin is on the World Health Organization's List of Essential Medicines
that are needed for a basic health system.
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