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738-70-5 Trimethoprim 2,4,6-Triisopropylthiophenol
Trimethoprim is a lipophilic weakly basic pyrimethamine bacteriostatic agent, also known as sulfa synergist, trimethoprim, antibacterial synergist, trimethoprim, trimethoprim, trimethyl Oxybenzylamine, trimethoprim, white or off-white crystalline powder at room temperature, odorless, bitter, slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water, easy to use in glacial acetic acid Dissolved. The antibacterial spectrum is similar to that of sulfa drugs, but it has strong antibacterial effect. It is effective against Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus aureus, and various Gram-positive and negative bacteria, but it is not effective against Pseudomonas aeruginosa infection. Often less than 10mg / L, single use is easy to cause bacterial resistance, it is generally not used alone, mainly with sulfa drugs constitute a compound preparation, clinically used to treat urinary tract infections, intestinal infections, respiratory tract infections, dysentery, enteritis , typhoid, meningitis, otitis media, meningitis, sepsis and soft tissue infections. The efficacy of typhoid fever and paratyphoid fever is not lower than that of ampicillin, and it can also be combined with long-acting sulfa drugs for the prevention and treatment of drug-resistant falciparum malaria.
product Name | trimethoprim |
---|---|
Synonyms | trimethoprim crystalline; 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyldiamine; Antibiotic synergist; 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine |
Molecular Formula | C14H18N4O3 |
Molecular Weight | 290.32 |
InChI | InChI=1/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) |
CAS Registry Number | 738-70-5 |
EINECS | 212-006-2 |
Melting point | 199-203°C |
Water solubility | <0.1 g/100 mL at 24°C |
1. Trimethoprim as an antimicrobial synergist can also treat bacterial infections and coccidiosis in poultry.
2. Trimethoprim New oral broad-spectrum antibiotics. Antibacterial spectrum and sulfa drugs similar and more effective, a variety of Gram-positive and negative bacteria effective. As the bacteria on the goods will easily lead to drug resistance, it should not be used as an antimicrobial alone. Trimethoprim and sulfa drug combination can enhance the antibacterial effect several times to several times.
3. Trimethoprim can also be used as veterinary drugs to treat septicemia caused by E. coli, chicken white diarrhea, fowls and cholera, cholera, respiratory secondary bacterial infections. Can also be used for the treatment of coccidiosis.
4. Trimethoprim antimicrobial synergistic drugs, used alone for respiratory infections, urinary tract infections, intestinal infections and other diseases
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