99% Imipramine Hydr...

99% Imipramine Hydrochloride Manufacturer 113-52-0 For Antidepressants

99% Imipramine Hydrochloride Manufacturer 113-52-0 For Antidepressants

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10 Gram

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  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : T/T,

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99% Imipramine hydrochloride Imipramine hydrochloride Manufacturer Antidepressants

Quick Details

  • Appearance:White Powder
  • Application: It Can Be Used As Pharmaceutical Intermediates, Or As Curing Agent Of Epoxy Resins, Etc
  • PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
  • ProductionCapacity:10000|Metric Ton|Month
  • Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
  • Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

 

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

Details:

Imipramine hydrochloride Basic information
Product Name: Imipramine hydrochloride
Synonyms: Imipramine hydrochloride,10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride;Imipramine Hydrochloride (200 mg);Methanol(test Imipramine HCl, 1.0 mg/mL as free base);Imipramine hydrochloride solution;10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine;5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride;tofranil;tofranile
CAS: 113-52-0
MF: C19H25ClN2
MW: 316.87
EINECS: 204-030-7
Product Categories: API;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor
Mol File: 113-52-0.mol
Imipramine hydrochloride Structure
 
Imipramine hydrochloride Chemical Properties
Melting point  168-1700C
Fp  9℃
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
form  crystalline
color  white
PH 4.2～5.2(100g/l,25℃)
Water Solubility  Soluble in water
λmax 260nm(lit.)
Merck  14,4920
CAS DataBase Reference 113-52-0(CAS DataBase Reference)
EPA Substance Registry System 5H-Dibenz[b,f]azepine- 5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride(113-52-0)
 
Safety Information
Hazard Codes  Xn,T,F
Risk Statements  23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11
Safety Statements  7-16-24-33-45-36-26-36/37
RIDADR  UN 1230 3/PG 2
WGK Germany  3
RTECS  HO1925000
TSCA  Yes
Toxicity LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)
 
Imipramine hydrochloride Usage And Synthesis
Chemical Properties White Solid
Uses Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters. Has little effect on the dopamine transporter
Uses Antidepressant;5-HT transport inhibitor
Brand name Janimine (Abbott); Pramine (Alra); Presamine (Sanofi Aventis); Tofranil (Novartis); Tofranil (Tyco).
General Description Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D2 postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H1block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).
Clinical Use The demethylated metabolite is less anticholinergic, lesssedative, and more stimulatory and is a SNERI.Consequently, a patient treated with imipramine has twocompounds that contribute to activity. Overall, the effect isnonselective 5-HT versus NE reuptake.

 

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