Indole-3-carbinol CAS 700-06-1 In stock 3-Hydroxymethylindole 3-Indolemethanol Indole-3-methanol

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Keywords

Indole-3-carbinol 3-Hydroxymethylindole 3-Indolemethanol

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Indole-3-carbinol CAS 700-06-1 In stock 3-Hydroxymethylindole 3-Indolemethanol Indole-3-methanol

700-06-1

CAS 700-06-1

3-Hydroxymethylindole; 3-Indolemethanol; Indole-3-methanol

Product Name: Indole-3-carbinol

Synonyms:

Indolemethanol; 3-(Hydroxymethyl)indole; 3-Indolemethanol; 1H-Indol-3-ylmethanol; Indole-3-methanol; 1H-Indole-3-methanol; I3C; AKOS NCG1-0099; 3-Indole methanol; Indo-3-Carbinol

CAS RN.:

700-06-1

EINECS: 211-836-2

Molecular Weight: 147.18

Molecular Formula: C9H9NO

Melting Point(℃): 96-99℃

Synonyms 3-Hydroxymethylindole; 3-Indolemethanol; Indole-3-methanol

Indole-3-carbinol (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale. It is also available in dietary supplements. Indole-3-carbinol is the subject of on-going biomedical research into its possible anticarcinogenic, antioxidant, and anti-atherogenic effects. Research on indole-3-carbinol has been conducted primarily using laboratory animals and cultured cells. Limited and inconclusive human studies have been reported. A recent review of the biomedical research literature found that "evidence of an inverse association between cruciferous vegetable intake and breast or prostate cancer in humans is limited and inconsistent" and "larger randomized controlled trials are needed" to determine if supplemental indole-3-carbinol has health benefits.

Basic Info

Chemical Name indole-3-methanol

Synonyms

INDOLE-3-METHANOL;

3-indolemethanol;

(1H-indole-3-yl)-methanol;

3-INDOLYLMETHANOL;

3-IndoleCarbinol;

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CAS No. 700-06-1

Molecular Formula C9H9NO

Molecular Weight 147.17400

PSA 36.02000

LogP 1.66020

Properties

Appearance & Physical State white to off white crystals

Density 1.272 g/cm3

Boiling Point 360.6ºC at 760 mmHg

Melting Point 96-99ºC

Flash Point 171.9ºC

Storage Condition 2-8ºC

Safety Info

RTECS NL9483000

Safety Statements S26-S36

HS Code 2933990090

WGK Germany 3

Risk Statements R36/38

Hazard Codes Xi

Indole-3-carbinol Basic information

Product Name: Indole-3-carbinol

Synonyms: Indole-3-carbinol,99.5%;Indole-3-carbinol 98%;(1H-Indol-3-yl)-methano;Indol-3-yl-methanol;3-INDOLAMETHANOL;INDOLE-3-CARBINOL:3-INDOLE METHANOL;INDOLE-3-CARBINOL(RG);3-HYDROXYMETHYLINDOLE(INDOLE-3-CARBINOL)

CAS: 700-06-1

MF: C9H9NO

MW: 147.17

EINECS: 211-836-2

Product Categories: blocks;IndolesOxindoles;indole derivative;Indoles and derivatives;IndoleDerivative;Pyrroles & Indoles;Indole;Indoles;Antioxidant;Biochemistry;Simple Indoles;Nutritional Supplements;Aromatics;Heterocycles;-;Halogenated Heterocycles ,Others;pharmaceutical raw material;Inhibitors;Pyrroles & Indoles;Heterocycle-Indole series

Mol File: 700-06-1.mol

Indole-3-carbinol Structure

Indole-3-carbinol Chemical Properties

Melting point 96-99 °C(lit.)

Boiling point 267.28°C (rough estimate)

density 1.1135 (rough estimate)

refractive index 1.5670 (estimate)

storage temp. 2-8°C

form Crystalline Powder or Flakes

color Off-white to yellow-orange

BRN 121323

Stability: 2-80C

InChIKey IVYPNXXAYMYVSP-UHFFFAOYSA-N

CAS DataBase Reference 700-06-1(CAS DataBase Reference)

Safety Information

Hazard Codes Xi

Risk Statements 36/38

Safety Statements 26-36

WGK Germany 3

RTECS NL9483000

Hazard Note Irritant

HS Code 29339900

MSDS Information

Provider Language

SigmaAldrich English

ACROS English

ALFA English

Indole-3-carbinol Usage And Synthesis

Chemical Properties Off-White Powder

Uses Inhibits cancinogenesis at the initiation stage. A metabolite of 3-methylindole

Uses antineoplastic; inhibitor of Amyloid-beta deposition

Uses nutritional supplement

Definition ChEBI: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.

Anticancer Research I3C is a bioactive compound majorly found in Brassica vegetables including broccoli,cauliflower, and collard greens. I3C and its derivative diindolylmethane (DIM)have been investigated for cancer prevention and treatment of breast, prostate, andovarian cancers. I3C partially modulates the tyrosine kinase/PI3K/Akt signalingpathway which leads to the prevention of lung adenocarcinoma which is induced byusing tobacco carcinogen in A/J mice. DIM transduces signaling via aryl hydrocarbon(Ah) receptor, NF-κB/Wnt/Akt/mTOR signaling pathways, cell cycle arrest,modulated cytochrome P450 enzymes, and altered angiogenetic and invasive,metastatic, and epigenetic behavior of cancer cells. Combination of DIM and I3Cinduces Nrf2-mediated phase II drug metabolizing genes (GSTm2, UGT1A1, andNQO1) and antioxidant genes (HO-1, SOD-1) (Weng et al. 2008; 2012).

Indole-3-carbinol Preparation Products And Raw materials

Raw materials 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE

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