dabigatran etexilate

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99（%）
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

dabigatran etexilate 211915-06-9 C34H41N7O5

Quick Details

Appearance: White crystalline powder
Application:Pharmaceuticals
PackAge:25KG/Cardboard bucket or as required
ProductionCapacity:5|Metric Ton|Month
Storage:cool and dry place
Transportation:by sea or by air

Superiority:

1 all ip developed as a service by tianma’s chemists, under a customer cda or msa, is the property of the customer. under customer cda or msa, all of the tianma chemists’ ip development service is belong to customers.

2 duty of confidentiality has been written in employment contract. and every employee should agree and sign it.

3 customer and tianma’s ip are protected by both side’s national law and company agreements.

electronic security access and information dissemination are controlled strictly.

1 secure vpn tunnels for email transfers confidential info to customers.

2 tianma central document server (cds) which can assigned security access, control the access of project specific information.

3 notebooks, mor’s and others are collected in archived room and be monitored under strict access.

4 only the basic information( need to know level) of the project details shared by related working group.

tianma has additional proactive employee training which emphasize about the law and risk of persecution and conviction:

1 regular retraining of tianma staff on ip protection and need for security.

2 inviting local police to introduce the latest criminal convictions of ip theft in china.

3 explanation of china patent law and customer cda‘s.

Dabigatran etexilate Basic information

Indications and Usage Mechanisms of Action Clinical Research Warnings and Precautions

Product Name:	Dabigatran etexilate
Synonyms:	Dabigatran Free Base;BIBR-1048 (Dabigatran);Dabigatran Etexilatr;BIBR-1048(Dabigatran etexilate);N-[2-[4-[N-(Hexyloxycarbonyl)aMidino]phenylaMinoMethyl]-1-Methyl-1H-benziMidazol-5-ylcarbonyl]-N-(2-;BIBR 1048;(E)-ethyl 3-(2-((4-(N'-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate;BIBR-1048, >=99%
CAS:	211915-06-9
MF:	C34H41N7O5
MW:	627.74
EINECS:	606-722-8
Product Categories:	-;Pharmaceutical intermediate;API;Dabigatran etexilate;Other APIs
Mol File:	211915-06-9.mol

Dabigatran etexilate Chemical Properties

Melting point

128-129°

Safety Information

MSDS Information

Dabigatran etexilate Usage And Synthesis

Indications and Usage	Dabigatran is the newest generation of oral anticoagulant drugs – direct thrombin inhibitors (DTIs), belonging to non-peptide thrombin inhibitors and instead specifically and selectively blocks the thrombin activity (free or bound) to prevent coagulation. Dabigatran targets the preventative and clinical treatment needs of acute and chronic thromboembolic disease.
Mechanisms of Action	It achieves anticoagulant effects through specific and selective inhibition of blood enzymes (free or bound). After oral ingestion and absorption through the digestive system, Dabigatran turns into Dabiga groups that have the direct anticoagulant abilities. By binding to thrombin in fibrin specific binding sites, Dabigatran stops fibrinogen from cleaving into fibrin, thus interrupting the blood clotting network and consequently thrombosis. Dabiga groups can also dissociate from the fibrin-thrombin coagulate and have an anticoagulating effect. Different from vitamin K antagonists, which affect different coagulants, Dabigatran can provide effective, predictable and stable anticoagulant effects. It will also have minimal reactions to other drugs or food, and does not require frequent monitoring or dosage adjustment.
Clinical Research	Compared to the control group treated with Warfarin, Dabigatran can significantly decrease the risk of stroke and embolic disease (including hemorrhagic stroke), greatly reduce the occurrence of bleeding (including fatal bleeding and intracranial hemorrhage), and greatly lower vascular mortality rate. Dabigatran provides effective and stable anticoagulant effects and does not require constant monitoring of anticoagulant functions or dosage adjustments.
Warnings and Precautions	1. Dabigatran is not to be used by patients with severe kidney damage (CrCl<30ml/min). 2. Patients with high bleeding risk should also not use Dabigatran. 3. Patients must be tested and monitored for signs of lack of bleeding or anemia; if there is severe bleeding, cease use of Dabigatran and identify the bleeding area. 4. Dabigatran is not suitable for patients with significant manifestations of rheumatic valvar heart disease or patients with artificial heart valves.
Description	Dabigatran etexilate is an orally administered pro-drug of dabigatran, which is a direct inhibitor of thrombin and a potent anticoagulant. The serine protease thrombin is the final mediator in the coagulation cascade that leads to the production of fibrin, the main protein component of blood clots. Thrombin is also a potent activator of platelets. Consequently, thrombin inhibitors have found utility as anticoagulants in treating arterial and venous thrombosis. Warfarin, although orally available, has a narrow therapeutic index and requires frequent monitoring and dosage adjustment. Low-molecular-weight heparins provide better safety profile and less inter-patient variability; however, these agents are only available for parenteral administration. Direct thrombin inhibitors (DTIs) are a new class of anticoagulants that act by directly binding to thrombin at its catalytic or fibrinogen-binding sites, or both. Unlike the heparins, DTIs do not require the activation of secondary factors such as antithrombin to derive their activity, which makes their action more predictable. In addition, their ability to inhibit both free and clot-bound thrombin predisposes them for enhanced anticoagulation effect.
Originator	Boehringer Ingelheim (Germany)
Uses	BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. It is being studied for various clinical indications and in many cases it offers an alternative to warfarin as the preferred orally administered blood thinner sin
Definition	ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-{N'-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amino group of thyl N-pyridin-2-yl-beta-alaninate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.
Brand name	Pradaxa
Chemical Synthesis	The chemical synthesis of dabigatran etexilate starts with the acylation of ethyl 3-(2-pyridylamino)propionate with 4-(methylamino)-3-nitrobenzoyl chloride to produce the corresponding amide. Subsequent reduction of the nitro group by catalytic hydrogenation, and cyclization of the resultant phenylenediamine with N-(4-cyanophenyl)glycine leads to a benzimidazole intermediate. The cyano group is then transformed into an amidine by employing the Pinner reaction. Finally, acylation of the amidino group with hexyl chloroformate gives rise to dabigatran etexilate.

Details:

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dabigatran etexilate