Phloretin

Phloretin
Phloretin
Phloretin

Phloretin

Min.Order / FOB Price:Get Latest Price

1 Metric Ton

Negotiable

  • Min.Order :1 Metric Ton
  • Purity: 98（%）
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Phloretin 60-82-2 C15H14O5

Quick Details

  • Appearance:powder
  • Application:C15H14O5
  • PackAge:25KG/Cardboard bucket or as required
  • ProductionCapacity:5|Metric Ton|Month
  • Storage:Store in dry, dark and ventilated place
  • Transportation:by air or by sea

Superiority:

 

Phloretin Basic information
Product Name: Phloretin
Synonyms: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one;2,4,6-Trihydroxy-B-(4-Hydroxyphenyl)Propiophenone;Phloretin,98%;β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone;PHLORETIN(RG);1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-;Dihydronaringenin;Floretin
CAS: 60-82-2
MF: C15H14O5
MW: 274.27
EINECS: 200-488-7
Product Categories: -;standardized herbal extract;Chalcones;All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).
Mol File: 60-82-2.mol
Phloretin Structure
 
Phloretin Chemical Properties
Melting point  ~260 °C
Boiling point  337.26°C (rough estimate)
density  1.1827 (rough estimate)
FEMA  4390 | 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE
refractive index  1.573-1.575
storage temp.  2-8°C
form  Powder
color  White to beige
Water Solubility  soluble
JECFA Number 2022
Merck  14,7326
BRN  1887240
InChIKey VGEREEWJJVICBM-UHFFFAOYSA-N
CAS DataBase Reference 60-82-2(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26-36
WGK Germany  3
F  3-10
HazardClass  IRRITANT
HS Code  29145090
 
 
Phloretin Usage And Synthesis
Chemical Properties Crystalline Solid
Chemical Properties White to pale yellow solid.
Uses A calcium channel protein inhibitor.
Uses The aglucon of Phlorizin. A glucose transport inhibitor. Also inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts.
Uses antidiabetic, inhibits glucose transport
Uses antioxidant cosmetic use
Definition ChEBI: A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.
Enzyme inhibitor This naturally occurring aglucon (FW = 274.27 g/mol; CAS 60-82-2) of phlorizin (or phloridzin) is generated from the latter by the action of bglucosidases, the phlorizin hydrolase activity of lactase, and by dilute mineral acids. Phloretin is soluble in ethanol and acetone. It is almost insoluble in water; however, the solubility is increased upon addition of ethanol. It adsorbs to lipid surfaces and alters the dipole potential of lipid monolayers and bilayers. Adsorption to biological and artificial membranes results in a change of the membrane permeability for a variety of charged and neutral compounds. Target(s): aldose 1-epimerase, or mutarotase; ATPases, chloroplast; Ca2+ channels, L-type; Ca2+- dependent ATPase; cAMP phosphodiesterase; b-carotene 15,15’- monooxygenase; chalcone isomerase; electron transport, chloroplast; fatty-acid synthase; glucose transport; glycogen phosphorylase; inositol-trisphosphate 3-kinase; iodothyronine deiodinase; lactate transport; L-leucine transport; Na+ and K+ uptake; oxidative phosphorylation (mitochondrial), uncoupler; phenylpyruvate tautomerase; photophosphorylation; prostaglandin F2a receptor; protein kinase C; pyruvate transport; starch phosphorylase; a,a-trehalase; tyrosinase, or monophenol monooxygenase; urea transport; and water permeability.
Purification Methods Crystallise phloretin from aqueous EtOH. [Zemplen & Bognár Chem Ber 75 1040 1942, Zemplén Chem Ber 76 386 1943, Beilstein 8 IV 3518.]

 

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Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.

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