Ketoprofen

Ketoprofen
Ketoprofen
Ketoprofen

Ketoprofen

Min.Order / FOB Price:Get Latest Price

1 Metric Ton

Negotiable

  • Min.Order :1 Metric Ton
  • Purity: 98（%）
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Ketoprofen 22071-15-4 C16H14O3

Quick Details

  • Appearance:White Crystalline Solid
  • Application:pharma intermediate
  • PackAge:25KG/Cardboard bucket or as required
  • ProductionCapacity:5|Metric Ton|Month
  • Storage:Stored in shaded, cool and dry places
  • Transportation:by air or by sea

Superiority:

 

Ketoprofen Basic information
Used in Particular Diseases
Product Name: Ketoprofen
Synonyms: ORUDIS;ORUVAIL;RARECHEM AL BO 1306;19583 RP;19583rp;2-(3-benzoylphenyl)-propionicaci;2-(m-Benzoylphenyl)propionic acid;2-(m-benzoylphenyl)propionicacid
CAS: 22071-15-4
MF: C16H14O3
MW: 254.28
EINECS: 244-759-8
Product Categories: Pharmaceutical ingredients;-;Pharmaceutical;Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling;Pharmaceutical raw material;API;ACTRON;Other APIs;Analgesics
Mol File: 22071-15-4.mol
Ketoprofen Structure
 
Ketoprofen Chemical Properties
Melting point  93-96°C
Boiling point  357.5°C (rough estimate)
density  1.1565 (rough estimate)
refractive index  1.5600 (estimate)
storage temp.  0-6°C
solubility  Slightly soluble in chloroform and methanol.
pka pKa 5.94(MeOH/H2O) (Uncertain)
form  solid
Merck  14,5305
InChIKey DKYWVDODHFEZIM-UHFFFAOYSA-N
CAS DataBase Reference 22071-15-4(CAS DataBase Reference)
NIST Chemistry Reference Ketoprofen(22071-15-4)
EPA Substance Registry System Benzeneacetic acid, 3-benzoyl-.alpha.-methyl-(22071-15-4)
 
Safety Information
Hazard Codes  T
Risk Statements  25-36/37/38-23/24/25
Safety Statements  26-45-36/37/39
RIDADR  2811
WGK Germany  3
RTECS  UE7570000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29183000
Toxicity LD50 orally in rats: 101 mg/kg (Ueno)
 
 
Ketoprofen Usage And Synthesis
Used in Particular Diseases Acute Gouty Arthritis:
Dosage and Frequency: 75 mg four times a day
Chemical Properties White Crystalline Solid
Uses Natural Vitamin B12. analog
Uses Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Uses Anti-inflammatory; analgesic
Definition ChEBI: An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Indications Ketoprofen (Orudis) is indicated for use in rheumatoid and osteoarthritis, for mild to moderate pain, and in dysmenorrhea. The most frequently reported side effects are GI (dyspepsia, nausea, abdominal pain, diarrhea, constipation, and flatulence) and CNS related (headache, excitation). Edema and increased blood urea nitrogen have also been noted in more than 3% of patients. Ketoprofen can cause fluid retention and increases in plasma creatinine, particularly in the elderly and in patients taking diuretics.
Brand name Actron (Bayer); Orudis (Wyeth); Oruvail (Wyeth).
General Description Ketoprofen (Orudis, Rhodis) and suprofen (Profenal) areclosely related to fenoprofen in their structures, properties,and indications. Even though ketoprofen has been approvedfor OTC use (Orudis KT, Actron), its GI side effects aresimilar to indomethacin, and therefore its useshould be closely monitored, especially in patients with GIor renal problems.
Contact allergens Ketoprofen is an anti-inflammatory drug, used both topically and systemically. It is above all a photoaller- gen, responsible for photoallergic or photo-worsened contact dermatitis, with sun-induced, progressive, severe, and durable reactions. Recurrent photosensitiv- ity is possible for many years. Photosensitivities are expected to thiophene-phenylketone derivatives such as tiaprofenic acid and suprofen, to ketoprofen esters such as piketoprofen, and to benzophenone derivatives (see above) such as fenofibrate and benzophenone-3. Concomitant photosensitivities without clinical rel- evance have been observed to fenticlor, tetrachloro- salicylanilide, triclosan, tribromsalan, and bithionol.
Veterinary Drugs and Treatments Ketoprofen is labeled for use in horses for the alleviation of inflammation and pain associated with musculoskeletal disorders. Like flunixin (and other NSAIDs), ketoprofen potentially has many other uses in a variety of species and conditions. There are approved dosage forms for dogs and cats in Europe and Canada. Some consider ketoprofen to be the NSAID of choice for use short-term for analgesia in cats.

 

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Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.

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