Andrographolide

Min.Order / FOB Price:Get Latest Price

1 Metric Ton	Negotiable

1 Metric Ton

Negotiable

Min.Order :1 Metric Ton
Purity: 99（%）
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Andrographolide 5508-58-7 C20H30O5

Quick Details

Appearance:powder
Application:C20H30O5
PackAge:25KG/Cardboard bucket or as required
ProductionCapacity:5|Metric Ton|Month
Storage:Store in dry, dark and ventilated place
Transportation:by air or by sea

Superiority:

Andrographolide Basic information

Description References

Product Name:	Andrographolide
Synonyms:	Andrographolide, 98%, from Andrographis paniculata;hylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-,(1r-(1-alpha(e(s*)),4a-be;3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl]ethylidene]dihydro-4-hydroxyfuran-2(3H)-one;Andrographalide;ANDROGRAPHOLIDE:2(3H)-FURANONE,3-[2-[(1R,4AS,5R,6R,8AS)-DECAHYDRO-6-HYDROXY-5-(HYDROXYMETHYL)-5,8A-DIMETHYL-2-METHYLENE-1-NAPHTHALENYL]ETHYLIDENE]DIHYDRO-4-HYDROXY-, (3E,4S)-,;2(3H)-Furanone, 3-2-(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenylethylidenedihydro-4-hydroxy-, (3E,4S)-;ANDROGRAPHOLIDE(P);3-[2-[Decahydro-6-hydroyx-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenylethylidene]dihydro-4-hydroxy-2(3H)-furanone
CAS:	5508-58-7
MF:	C20H30O5
MW:	350.45
EINECS:	226-852-5
Product Categories:	Di-Terpenoids;Asymmetric Synthesis;Chiral Building Blocks;Complex Molecules;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;plant extract-;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Herb extract;chemical reagent;natural product;-;pharmaceutical intermediate;phytochemical
Mol File:	5508-58-7.mol

Andrographolide Chemical Properties

Melting point	229-232 °C(lit.)
alpha	-126 º (c=1.5,HAc)
density	d421 1.2317
storage temp.	+2C to +8C
form	Off-white solid
optical activity	[α]20/D 126°, c = 1.5 in acetic acid
λmax	223nm(MeOH)(lit.)
Merck	14,633
BRN	42762
InChIKey	BOJKULTULYSRAS-QPSYGYIJSA-N
CAS DataBase Reference	5508-58-7

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
RTECS	LU3490750
HS Code	29322980

Andrographolide Usage And Synthesis

Description	Andrographolide is the bitter principle, a colorless and neutral crystalline substance. It is the major labdane diterpenoid isolated from Andrographis paniculate. It exhibits antiviral, anti-inflammatory, and anticancer activities. The underlying mechanism is the inhibition of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling (specifically p38 MAPK/ERK1/2) pathway and downstream transcription factors such as nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT). Andrographolide is also confirmed with chemopreventive effects against and the inhibitory effects on cancer cell growth in breast, colon, epidermoid, gastric, liver, leukemia, myeloma, peripheral blood lymphocytes, and prostate cancers. Andrographolide has been used for liver complaints and fever, and as an anti-inflammatory and immunostimulant. Andrographolide exerts anti-growth and pro-apoptotic effects on human rheumatoid arthritis fibroblast- like synoviocytes, the main cellular constituent of pannus, that combined with a massive infiltration of lymphocytes and macrophages, invades and destroys the local articular structure. Thereby, andrographolide is proposed to be used in Rheumatoid Arthritis and other autoimmune diseases.
References	[1] Mari a A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A. Burgos (2013) Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease in book “Innovative Rheumatology” [2] # [3] Mitchell Low, Cheang S Khoo, Gerald Münch, Suresh Govindaraghavan, Nikolaus J Sucher (2014) An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide, BMC Complementary and Alternative Medicine, 15:18
Chemical Properties	colorless Plates
Uses	Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.
Uses	antineoplastic
Definition	ChEBI: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Anticancer Research	It is a labdane diterpenoid, which shows cytotoxic effect against different cancercell lines like human epidermoid cancer cells (KB), lymphocytic leukemia cells(P388), breast cancer cells (MCF-7), and colon cancer cells (HCT-116). It inhibitsthe proliferation of colon cancer cells (HT-29) and exerts pro-differentiative effecton mouse myeloid leukemia M1 cell line (Desai et al. 2008).

Andrographolide Preparation Products And Raw materials

Raw materials

Etanol

Details:

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Andrographolide