Rapamycin CAS NO.53123-88-9

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5 Gram	Negotiable

5 Gram

Negotiable

Min.Order :5 Gram
Purity: 99%min
Payment Terms : T/T,,MoneyGram,Other

Keywords

Sodium Chloride Rapamycin titanium dioxide

Quick Details

Appearance:Colorless tripartite crystal or diamond crystals
Application:used in the manufacture of weed killing compositions
PackAge:1kgor 5kg/bag, 25kg/drum
ProductionCapacity:10000|Metric Ton|Month
Storage:keep dry
Transportation:by express , by sir , by sea etc.

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Details:

Product Name:	Rapamycin
Synonyms:	AY 22989;23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE;NSC-226080;RAPA;RAPAMUNE;RAPAMYCIN;RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS;RPM
MF:	C51H79NO13
MW:	914.18
EINECS:	262-640-9
Product Categories:	Active Pharmaceutical Ingredients;Immunosuppressant;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Signalling;API;Chiral Reagents;Heterocycles;Inhibitor;VIVACTIL;antibiotic
Mol File:	53123-88-9.mol

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP(RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is

potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.

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