Dihydromyricetin,Am...

Dihydromyricetin,Ampelopsin,Ampeloptin

Dihydromyricetin,Ampelopsin,Ampeloptin

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: >98%
  • Payment Terms : T/T,Other

Keywords

Dihydromyricetin Ampelopsin Ampeloptin

Quick Details

  • Appearance:white powder
  • Application:Dihydromyricetin is a potent dihydropyrimidinase inhibitor with an IC50 of 48 μM. Dihydromyricetin activates autophagy by inhibiting mTOR signaling
  • PackAge:25kg per bag
  • ProductionCapacity:500|Metric Ton|Week
  • Storage:keep in cool and dry
  • Transportation:by sea or air

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Details:

 

Dihydromyricetin Basic information
Product Name: Dihydromyricetin
Synonyms: 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol;3,3’,4’,5,5’,7-hexahydroxy-flavanon;ampelopsin(flavanol);ampeloptin;DIHYDROMYRICETIN(RG);(+)-Dihydromyricetin;(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
CAS: 27200-12-0
MF: C15H12O8
MW: 320.25
EINECS: 200-001-8
Product Categories: Flavanones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors
Mol File: 27200-12-0.mol
Dihydromyricetin Chemical Properties
storage temp.  20°C
solubility  DMSO: ≥5mg/mL (warmed)
color  white to beige
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
 
Safety Information
Safety Statements  24/25
HS Code  29329990
Dihydromyricetin Basic information
Product Name: Dihydromyricetin
Synonyms: 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol;3,3’,4’,5,5’,7-hexahydroxy-flavanon;ampelopsin(flavanol);ampeloptin;DIHYDROMYRICETIN(RG);(+)-Dihydromyricetin;(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
CAS: 27200-12-0
MF: C15H12O8
MW: 320.25
EINECS: 200-001-8
Product Categories: Flavanones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors
Mol File: 27200-12-0.mol
Dihydromyricetin Structure
 
Dihydromyricetin Chemical Properties
storage temp.  20°C
solubility  DMSO: ≥5mg/mL (warmed)
color  white to beige
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
 
Safety Information
Safety Statements  24/25
HS Code  29329990
Dihydromyricetin bioactivity
Description Dihydromyricetin is a potent dihydropyrimidinase inhibitor with an IC50 of 48 μM. Dihydromyricetin activates autophagy by inhibiting the mTOR signal. Dihydromyricetin inhibits the formation of the mTOR complex (mTORC1/2).
Related category
Signal Pathway >> Autophagy >> Autophagy
Research Fields >> Cancer
Natural Products >> Flavonoids
Target
Dihydropyrimidinase: 48 μM (IC50)
 
mTORC1
 
mTORC2
 
Autophagy
 
In vitro studies Dihydromyricetin, a flavonol, significantly inhibits the catalytic activity of dihydropyrimidinase on the natural substrate dihydrouracil and the isoform substrate 5-propyl-hydantoin. Dihydromyricetin showed a significant inhibitory effect on the activity of dihydropyrimidin on both substrates, and even more inhibited than myricetin. The IC50 values ??of dihydromyricetin to dihydropyrimidin determined using a titration curve of dihydrouracil and 5-propylhydantoin were 48±2 and 40±2 μM, respectively [1]. During D-gal administration, dihydromyricetin (DHM) supplementation significantly reversed the increase in mTOR phosphorylation on Ser2448 (p-mTOR), suggesting that dihydromyricetin can activate autophagy by inhibiting mTOR signaling [ 2].
In vivo studies were evaluated by Morris water maze (MWM) in the normal control group, D-gal group, D-gal + dihydromyricetin (100 mg / kg) group, D-gal + dihydromyricetin (200 mg / kg) group. Changes in learning and memory in rats) (n = 10 per group). Compared with the D-gal-induced model group, dihydromyricetin (DHM) treatment significantly shortened the escape latency [2].
Solubility
in vitro:
DMSO: ≥100mg / mL (312.26 mM)
 
* “≥” means soluble, but the saturation is unknown.
 
In vivo: 1. Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: ≥2.5 mg / mL (7.81 mM); clear solution 2. Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline solubility: ≥ 2.5 mg / mL (7.81 mM); clear solution 3. Add each solvent one by one: 10% DMSO 90% corn oil Solubility: ≥ 2.5 mg / mL (7.81 mM); Clear solution
Stock solution
1 mM 3.1226 mL 15.6128 mL 31.2256 mL
5 mM 0.6245 mL 3.1226 mL 6.2451 mL
10 mM 0.3123 mL 1.5613 mL 3.1226 m

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