chemical reagent Fine Chemicals Pharmaceutical Intermediates
3,5-Dimethylhydroquinone;4-Benzenediol,2,6-dimethyl-1;Dmhq;Hydroquinone, 2,6-dimethyl-;Metaxylohydroquinone;mxhq;m-XHQ;m-Xylene-2,5-diol
Application and synthesis method 2, 6-dimethyl-1, 4-diphenylene (reagent grade) upstream and downstream product information
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1. Acute toxicity: mice (oral) LD50:186 mg/kg;
Rats (oral) LD50:117 mg/kg
Cat (peritoneum) LDLo: 20mg/kg
Since the LD50 of table salt is 3,000 mg/kg, the acute toxicity of BPA is the same as that of table salt.
2. Reproductive toxicity: female (oral) : TDLo: 84mg/kg/ week (30 weeks)
Male (oral) : TDLo: 7,143 mu /kg/ day
Female rats (oral) : TDLo: 100mg/kg
Female rats (peritoneum) : TDLo: 950mg/kg/ day
Female rats (oral) : TDLo: 3mg/kg/ day
Female rats (subcutaneous) : TDLo: 200mg/kg/ day
Female rats (not reported) : TDLo: 50mg/kg/ day
Female mice (oral) : TDLo: 40mg/kg/ day
Rat reproductive toxicity test: 1 generation NOAEL: 1000 parts per million (the equivalent of 50 mg/kg/day に).It doesn't make any difference.
Two generation reproductive toxicity test in mice: the lowest dose of 2500 parts per million (437 mg/kg/day に), abnormal.Increased kidney and liver weight and decreased penis weight.Because the amount is too high, NOAEL cannot come out.
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