Propylthiouracil/99%

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99（%）
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Propylthiouracil 51-52-5 Propylthiouracil supplier

Quick Details

Appearance:white powder
Application:PharmaIntermediate
PackAge:25KG/Cardboard bucket or as required
ProductionCapacity:5|Metric Ton|Month
Storage:Keep in dry and cool place and away from sunshine
Transportation:by sea or by air

Superiority:

Propylthiouracil Basic information

Product Name:	Propylthiouracil
Synonyms:	2,3-dihydro-6-propyl-2-thioxo-4(1h)-pyrimidinon;2,3-dihydro-6-propyl-2-thioxo-4(1h)pyrimidinone;2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone;2-Mercapto-4-hydroxy-6-n-propylpyrimidine;2-Mercapto-6-propyl-4-pyrimidone;4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-;6-n-Propylthiouracil;6-Propil-tiouracile
CAS:	51-52-5
MF:	C7H10N2OS
MW:	170.23
EINECS:	200-103-2
Product Categories:	Pyridines, Pyrimidines, Purines and Pteredines;Intermediates & Fine Chemicals;-;Pharmaceuticals;API's;REN-O-SAL;Other APIs;steroids;AZD929
Mol File:	51-52-5.mol

Propylthiouracil Chemical Properties

Melting point	218-220 °C(lit.)
density	1.1880 (rough estimate)
refractive index	1.5960 (estimate)
Fp	300 °C
storage temp.	Refrigerator
solubility	1.1g/l
pka	pKa 7.8; 8.3 (Uncertain)
form	neat
PH	6-7.5 (5g/l, H2O, 20℃)(slurry)
Water Solubility	1.1 g/L
Merck	14,7869
BRN	130039
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.
CAS DataBase Reference	51-52-5(CAS DataBase Reference)
NIST Chemistry Reference	Tegretol(51-52-5)
EPA Substance Registry System	4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo- (51-52-5)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-40
Safety Statements	36/37-45
WGK Germany	3
RTECS	YR1400000
Hazard Note	Harmful/Irritant
HS Code	29335995
Hazardous Substances Data	51-52-5(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 1250 mg/kg

Propylthiouracil Usage And Synthesis

Chemical Properties	White Crystalline Powder
Chemical Properties	White crystalline solid or powder. Odorless. Bitter taste.
Uses	Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen
Uses	antibacterial
Definition	ChEBI: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.
General Description	Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.
General Description	Propylthiouracil, 6-propyl-2-thiouracil (Propacil), is a stable, white, crystalline powderwith a bitter taste. It is slightly soluble in water but readilysoluble in alkaline solutions (salt formation).
Air & Water Reactions	Sensitive to light. May be sensitive to prolonged exposure to air. Insoluble in water.
Reactivity Profile	Propylthiouracil is incompatible with strong oxidizing agents, strong acids and strong bases. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . When reduced will produce hydrogen sulfide.
Hazard	Possible carcinogen.
Fire Hazard	Flash point data for Propylthiouracil are not available; however Propylthiouracil is probably combustible.
Clinical Use	Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients.
Safety Profile	Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects: agranulocytosis, hepatitis, jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the endocrine system and changes in newborn viability. Human and experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also MERCAPTANS.
Potential Exposure	Medication (antihyperthyroid; thyroid inhibitor) with human and veterinary applications.
Carcinogenicity	Propylthiouracil is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping	UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods	Purify propacil by recrystallisation from H2O (soluble in 900 parts at 20o, and 100 parts at 100o). UV, MeOH: max 277nm. [Anderson et al. J Am Chem Soc 67 2197 1945, Vanderhaegue Bull Soc Chim Belg 59 689 1950, Beilstein 24 III/IV 1333.]
Incompatibilities	This chemical is probably combustible; it’s dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . Sensitive to light and may be sensitive to air.
Waste Disposal	It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding to trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely pack- age the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

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Propylthiouracil/99%