Benazepril

Benazepril
Benazepril
Benazepril

Benazepril

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99（%）
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Benazepril 86541-75-5 C24H28N2O5

Quick Details

  • Appearance:powder
  • Application:Pharmaceutical Intermediates
  • PackAge:As required
  • ProductionCapacity:5|Metric Ton|Month
  • Storage:Store in dry, dark and ventilated place
  • Transportation:by sea or by air

Superiority:

Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.

Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.

Changzhou Xuanming Chemical CO., LTD promises to help you with heart and soul.

Details:

 
Benazepril Basic information
Product Name: Benazepril
Synonyms: 2-[(4s)-4-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-6-azabicyclo[5.4.0]undeca-7,9,11-trien-6-yl]acetic acid;BENAZCPRIL;genazepril;BENAZEPRIL HCL, RELATED COMPOUND B(3S)-3-[[(1R)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-2,3,4,5-TETRAHYDRO-2-OXO-1H-1-BENAZAPINE-1-ACETIC ACID, MONOHYDROCHLORIDE USP STANDARD;BENAZEPRIL HCL, MM(CRM STANDARD);BENAZEPRIL HCL, USP STANDARD;BENAZEPRIL HCL USP(CRM STANDARD);BENAZEPRIL MM
CAS: 86541-75-5
MF: C24H28N2O5
MW: 424.49
EINECS:  
Product Categories: -;Active Pharmaceutical Ingredients;Antihypertensive;API
Mol File: 86541-75-5.mol
Benazepril Structure
 
Benazepril Chemical Properties
Melting point  148-149°
alpha  D -159° (c = 1.2 in ethanol)
CAS DataBase Reference 86541-75-5(CAS DataBase Reference)
 
Safety Information
Safety Statements  22-24/25
 
Benazepril Usage And Synthesis
Definition ChEBI: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzy e inhibitor benazeprilat in the treatment of hypertension and heart failure.
Enzyme inhibitor This ACE-directed pro-drug (FWfree-acid = 424.50 g/mol; CAS 86541-75-5), also known as 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5- tetrahydro-2-oxo-(S-(R*,R*))-1H-1-benzazepine-1-acetic acid, Lotensin and CGS 14824A, is rapidly metabolized to its diacid benazeprilat (CGS 14831; FWfree-diacid = 396.44 g/mol), the latter a potent, long-acting inhibitor of peptidyl-dipeptidase A, or angiotensin I-converting enzyme, IC50 = 1.7 nM. Lotensin is used to treat hypertension, congestive heart failure, and chronic renal failure. The antihypertensive effects of benazepril begin as early as 30 min after a single dose, and those effects during consecutive dosing are also sustained for 24 h with a lesser diurnal variation in blood pressure

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