Azelastine hydrochloride

Min.Order / FOB Price:Get Latest Price

10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: 99（%）
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Azelastine hydrochloride 79307-93-0 C22H25Cl2N3O

Quick Details

Appearance:white crystalline powder
Application:Pharmaceutical Intermediates
PackAge:As required
ProductionCapacity:5|Metric Ton|Month
Storage:Keep in a cool & dry place
Transportation:by sea or by air

Superiority:

Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.

Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.

Changzhou Xuanming Chemical CO., LTD promises to help you with heart and soul.

Details:

Azelastine hydrochloride Basic information

Product Name:	Azelastine hydrochloride
Synonyms:	4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride;Allergodil;Astelin;Optilast;Rhinolast;Aselastine;1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride;Acelastine hydrochloride
CAS:	79307-93-0
MF:	C22H25Cl2N3O
MW:	418.36
EINECS:	620-469-0
Product Categories:	Antihistaminic;Intermediates & Fine Chemicals;-;Pharmaceuticals;Histamine receptor;Astelin
Mol File:	79307-93-0.mol

Azelastine hydrochloride Chemical Properties

Melting point	225--2290C
storage temp.	-20°C Freezer
solubility	DMSO: >10mg/mL
form	powder
color	white to off-white
Merck	14,906
Stability:	Incompatible with strong oxidizing agents.
CAS DataBase Reference	79307-93-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22
RTECS	TH9203900
HS Code	2933992600
Toxicity	LD50 in male, female mice, male, female rats (mg/kg): 36.5, 35.5, 26.9, 30.3 i.v.; 56.4, 42.8, 43.2, 46.6 i.p.; 63.0, 54.2, 66.5, 59.6 s.c.; 124, 139, 310, 417 orally (Zechel)

MSDS Information

Azelastine hydrochloride Usage And Synthesis

Description	Azelastine hydrochloride is an orally effective antihistamine useful in the treatment of asthma and nasal allergy. It appears to inhibit release of histamine, in addition to antagonizing its action.
Chemical Properties	White or almost white, crystalline powder.
Originator	Asta-Werke(Degussa) (W. Germany)
Uses	Orally active H1-hystamine receptor antagonist. Antihistaminic
Definition	ChEBI: The hydrochloride salt of azelastine.
Brand name	Astelin (Medpointe); Optivar (Medpointe);AZEPTIN.
General Description	(±)-4-[(4-chlorophenyl)methyl]-2-(hexahydro-l-methyl-1H-azepin-4-yl)-l-(2H)-phthalazinone monohydrochloride (Optivar), is a whitecrystalline powder that is sparingly soluble in water,methanol, and propylene glycol and slightly soluble inethanol, octanol, and glycerine. The commercial preparationis available as a 0.05% sterile ophthalmic solution fortopical administration to the eyes. Each milliliter of azelastinesolution contains 0.5-mg azelastine hydrochlorideequivalent to 0.457 mg of azelastine base, the preservativebenzalkonium chloride (0.125 mg), and inactive ingredientsincluding disodium edetate dihydrate, hydroxypropylmethylcellulose,sorbitol solution, sodium hydroxide, andwater for injection. The solution has a pH of approximately5.0 to 6.5 and an osmolality of approximately 271to 312 mOsm/L. The recommended dose of azelastine solution is 1 dropinstilled into each affected eye twice a day. This drugproduct is for ocular administration only and not for injectionor oral use. Absorption of azelastine following ocularadministration is relatively low (less than 1 ng/rnL).Absorbed drug undergoes extensive oxidative N-demethylationby CYP, and the parent drug and metabolite are eliminatedprimarily in the feces. The most frequently reportedadverse reactions are transient eye burning or stinging,headaches, and bitter taste. Azelastine solution should beused with caution during pregnancy or while nursing, becauseits safety has not been studied under these circumstances.

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