Clevidipine butyrate

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Clevidipine butyrate 167221-71-8 C21H23Cl2NO6

Quick Details

Appearance:white to off-white powder
Application:PharmaIntermediate
PackAge:As required
ProductionCapacity:5|Metric Ton|Month
Storage:keep in dry and cool condition
Transportation:by sea or by air

Superiority:

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Details:

Clevidipine butyrate Basic information

Product Name:	Clevidipine butyrate
Synonyms:	Clevidipine, Cleviprex;Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dime thyl-3,5-pyridinedicarboxylate;4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-Pyridinedicarboxylic acid methyl (1-oxobutoxy)methyl ester;Clevidipine butyrate;Cleviprex;3,5-Pyridinedicarboxylicacid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-methyl5-[(1-oxobutoxy)methyl] ester;Clevidipine Butyrate/Cleviprex;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(1-Oxobutoxy)Methyl] Ester
CAS:	167221-71-8
MF:	C21H23Cl2NO6
MW:	456.32
EINECS:	682-702-2
Product Categories:	-;Aromatics;Pharmaceuticals;Clevidipine Butyrate impurity;Heterocycles;Intermediates & Fine Chemicals;Cardiovascular APIs
Mol File:	167221-71-8.mol

Clevidipine butyrate Chemical Properties

Melting point	128-130°C
density	1.289
Fp	280℃
storage temp.	Refrigerator

Safety Information

Safety Statements	24/25
HS Code	29339900

MSDS Information

Clevidipine butyrate Usage And Synthesis

Description	Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine (DHP) class of CCB. It is indicated as an intravenous treatment for the acute management of hypertension when oral therapy is not feasible or not desirable. Clevidipine is the second intravenous CCB to be marketed behind nicardipine for this indication. Both agents are primarily used for urgent treatment of hypertension in cardiac surgical setting, intensive care units, and emergency departments. Other intravenous agents currently on the market for this indication include sodium nitroprusside, nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect on the myocardial contractility and venous capacitance. It has a rapid onset and offset of action and a very short plasma half-life, which allows for titration of the drug to achieve precise BP control. clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.
Chemical Properties	White to Off-White Solid
Originator	AstraZeneca (United Kingdom)
Uses	Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。
Uses	Calcium channel blocker, used as an oral antihypertensive.
Uses	Seroquel XR
Uses	A calcium channel protein inhibitor and blocker
Brand name	Clevelox (The Medicines Company).
Side effects	Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile.
Chemical Synthesis	The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile. The DHP-monoester starting material is obtained in two steps through condensation of methyl 2,3-dichlorobenzylidine acetoacetate and 2-cyanoethyl ester of 2-amino-2-propenoic acid to the DHP diester, followed by base catalyzed cleavage of the cyanoethyl group. Clevidipine is practically insoluble in water and is formulated in an oil-inwater emulsion.

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Clevidipine butyrate