Tiotropium bromide,cas:136310-93-5 cas:136310-93-5 Tiotropium bromide
Tiotropium bromide (INN) is a long-acting, 24 hour, anticholinergicbronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium bromide capsules for inhalation are co-promoted by Boehringer-Ingelheim and Pfizer under the trade nameSpiriva. It is also manufactured and marketed by Cipla under trade nameTiova.
Systematic (IUPAC) name | |
---|---|
(1α,2β,4β,7β)- 7-[(hydroxidi-2-thienylacetyl)oxy]-9,9-dimethyl- 3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide |
|
Clinical data | |
MedlinePlus | a604018 |
Pregnancy cat. | B1 (AU) |
Legal status | Prescription Only (S4)(AU) POM (UK) -only(US) |
Routes | Inhalation (oral) |
Pharmacokinetic data | |
Bioavailability | 19.5% (inhalation) |
Metabolism |
Hepatic 25% (CYP2D6, CYP3A4) |
Half-life | 5–6 days |
Excretion | Renal |
Identifiers | |
CAS number |
136310-93-5 186691-13-4 (cation) |
ATC code | R03BB04 |
PubChem | CID 5487426 |
IUPHAR ligand | 367 |
DrugBank | DB01409 |
ChemSpider | 10482095 |
UNII | XX112XZP0J |
ChEMBL | CHEMBL1201307 |
Chemical data | |
Formula | C19H22BrNO4S2 |
Mol. mass | 472.416 g/mol |
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