Antennapedia Peptide

Antennapedia Peptide

Antennapedia Peptide

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1 Milligram

Negotiable

  • Min.Order :1 Milligram
  • Purity: 95%;98%;99%
  • Payment Terms : T/T

Keywords

Antennapedia Peptide 188842-14-0 RQIKIWFQNRRMKWKK-NH2

Quick Details

  • Appearance:Whithe powder
  • Application:Research
  • PackAge:According customer's requirements
  • ProductionCapacity:1-1000|Gram|Day
  • Storage:keep in dry,cool
  • Transportation:According customer's requirements

Superiority:

Shanghai Apeptide Co.,Ltd is one of famous-peptide manufacturers in China.
For 10 years we have supplied peptides/API pepitdes/Custom Peptide/ Amino acides/ protein etc...
Our website address:   www.apeptides.com/en/
We have amyloid peptides libs and supply high quality\competetive price\best service.
 
We Supply :
Peptide   
Custom pepitdes synthesis
Amino acids/Unusual amino acids
Custom amino acid synthesis
Protein expression
 
We can do:
Custom Peptide Modifications
         o Amidation,C-termainal
         o Aldehydes,C-termainal
         o Alcohols,C-termainal
         o pNA (p-Nitroanilide),C-termainal
         o AMC,C-termainal
         o AFC,C-termainal
         o Cysteamide,C-termainal
         o Ester,C-termainal
         o N-Alkyl Amides,N-termainal  
         o Acetylated,N-termainal 
         o Palmytolyl,N-termainal 
         o HYNIC,N-termainal 
         o Biotinylated,N-termainal 
         o Bromoacetylated,N-termainal 
         o DOTA，DTPA conjugated,N-termainal 
         o Formylated,N-termainal 
         o Myristoylated,N-termainal 
         o Succinylated,N-termainal 
 Dye-labeled peptides
       AFC, AMC, Lys(Dye), pNA, Rh110 
 N-terminal Modifications
       Bodipy-FL, Cy3, Cy5, Texas Red, 5-Tamra, 5-lodoacetamido fluorescein
       Rhodamine 110 and Rhodamine B Luciferin, EDANS
       FAM, FITC, MCA, Rox, Sulforhodamine 101, 5-TAMRA  
Cyclic peptides
        o N -> C or Head to Tail o Disulfide (S-S bond formation) .Trisulfide formation）
        o Cyclic-natural peptides 
 Methylated peptides
        o Lys(For),Lys(Me), Lys(Me)2, Lys(Me)3, Arg(Me)2 symmetrical, D-Tyr(Me),D-Tyr(Et)
        o Na-Methylated（N-Me-Arg,N-Me-Asp, N-Me-Glu, N-Me-Leu, N-Me-Nle, N-Me-Nva, N-Me-Phe, N-Me-S N-Me-Ser, N-Me-Trp, N-Me-Thr, N-Me-Val）
Other modifications
       o BSA, KLH conjugated peptides for antibody production ）
       o Phosphoserine, Phosphothreonine, Phosphotyrosine
       o Sulfated Tyrosine or Serine
       o MAPS (Multiple Antigenic Peptide) 
       o Glycopeptides
       o PEGylation
       o Peptidomimetics
 
 
 
 

Details:

Description

Antennapedia Peptide is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of Cell-penetrating peptides.
In Vitro

Antennapedia (Antp)-SMCC-cytochrome c conjugate (5 μg/mL) activates caspase-dependent apoptosis of HeLa cells. The Antp-SMCC-cytochrome c conjugate reduces the clonogenic survival of Hela cells, and inhibits clonogenic survival[1]. ANTP-SmacN7 fusion protein can transduce and accumulate in cells, while SmacN7 alone cannot. ANTP-SmacN7 fusion proteins have a radiation-sensitising effect on EC109 cells. ANTP-SmacN7 combined with radiation does not promote further increases in caspase-3 protein expression, it increases the levels of cleaved caspase-3[2].
Molecular Weight

2246.80
Formula

C???H???N??O??S
CAS No.

188842-14-0
Sequence

Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys
Sequence Shortening

RQIKIWFQNRRMKWKK
Shipping

Room temperature in continental US; may vary elsewhere
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References

  • [1]. Imesch P, et al. Conjugates of cytochrome c and antennapedia peptide activate apoptosis and inhibit proliferation of HeLa cancer cells. Exp Ther Med. 2013 Sep;6(3):786-790. Epub 2013 Jul 4.

    [2]. Du LQ, et al. Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells. Int J Mol Sci. 2013 Dec 11;14(12):24087-96.

 

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