CasNo.952143-02-1,3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine,3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine(952143-02-1) Suppliers

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Suzuki-Miyaura-compatible multifunctional photo probe building block Trifluoromethyl diazirine aryl bromide 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

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Appearance:3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S?M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of gr...
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3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S?M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.