2,2'-[5-(1H-1,2,4-T...

2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)benzol-1,3-diyl]bis(2-methylpropanonitril)

2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)benzol-1,3-diyl]bis(2-methylpropanonitril)

Min.Order / FOB Price:Get Latest Price

1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99.8%
  • Payment Terms : ,Other

Keywords

Arimidex Anastrozole stimulant steroid

Quick Details

  • Appearance:Crystalline solid
  • Application:For research purposes only
  • PackAge:Discreet packing ways as your requirements
  • ProductionCapacity:100|Kilogram|Day
  • Storage:Keep in a cool and dry place
  • Transportation:shipping by EMS,DHL,TNT,FEDEX,UPS or as customer requirements

Superiority:

Medical uses
Breast cancer
Anastrozole is used in the treatment and prevention of breast cancer in women. The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial was of localized breast cancer and women received either anastrozole, the selective estrogen receptor modulator tamoxifen, or both for five years, followed by five years of follow-up. After more than 5 years the group that received anastrozole had better results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized estrogen receptor-positive breast cancer.
 
Early puberty
Anastrozole is used at a dosage of 0.5 to 1 mg/day in combination with the antiandrogen bicalutamide in the treatment of peripheral precocious puberty, for instance due to familial male-limited precocious puberty (testotoxicosis) and McCune–Albright syndrome, in boys.
 
Pharmacology
Pharmacodynamics
Anastrozole works by reversibly binding to the aromatase enzyme, and through competitive inhibition blocks the conversion of androgens to estrogens in peripheral (extragonadal) tissues. The medication has been found to achieve 96.7% to 97.3% inhibition of aromatase at a dosage of 1 mg/day and 98.1% inhibition of aromatase at a dosage of 10 mg/day in humans. As such, 1 mg/day is considered to be the minimal dosage required to achieve maximal suppression of aromatase with anastrozole. This decrease in aromatase activity results in an 85% decrease in estradiol levels in postmenopausal women. Levels of corticosteroids and other adrenal steroids are unaffected by anastrozole.
 
Pharmacokinetics
The bioavailability of anastrozole in humans is unknown, but it was found to be well-absorbed in animals. Absorption of anastrozole is linear over a dosage range of 1 to 20 mg/day in humans and does not change with repeated administration. Food does not significantly influence the extent of absorption of anastrozole. Peak levels of anastrozole occur a median 3 hours after administration, but with a wide range of 2 to 12 hours. Steady-state levels of anastrozole are achieved within 7 to 10 days of continuous administration, with 3.5-fold accumulation. However, maximal suppression of estradiol levels occurs within 3 or 4 days of therapy.
 
Active efflux of anastrozole by P-glycoprotein at the blood–brain barrier has been found to limit the central nervous system penetration of anastrozole in rodents, whereas this was not the case with letrozole and vorozole. As such, anastrozole may have peripheral selectivity in humans, although this has yet to be confirmed. The plasma protein binding of anastrozole is 40%.
 
The metabolism of anastrozole is by N-dealkylation, hydroxylation, and glucuronidation. Inhibition of aromatase is due to anastrozole itself rather than to metabolites, with the major circulating metabolite being inactive. The elimination half-life of anastrozole is 40 to 50 hours (1.7 to 2.1 days). This allows for convenient once-daily administration. The medication is eliminated predominantly by metabolism in the liver (83 to 85%) but also by residual excretion by the kidneys unchanged (11%). Anastrozole is excreted primarily in urine but also to a lesser extent in feces.

 

Details:

FAQ
1. Can I get a free sample
Yes, but you have to pay the courier fee.
2. How to pay
We accept payments in the form of , MoneyGram, Bitcoin, etc.
3. What should I do if we don’t ship after payment
We are a formal company certified by LOOKCHEM Integrity, you can provide proof of payment to LOOKCHEM complaints.
4. How long after the payment can be shipped
We have stocked products that are shipped within 24 hours. If you need to customize the product, we will negotiate the delivery cycle.
5. How is the safety of transportation
We will choose the safest delivery method to ensure customs clearance and safety during transportation.
6. What kind of company is THETA BIO
  In 2009, Dr Zhang Lin from Johns Hopkins University founded the theta Biological Laboratory. He is committed to the study of protein assimilation preparations.
   In 2013,Dr Zhang Lin returned to China to work in MSD China, and continued to work on biopharmaceutical research and development.
   In 2018,Dr Zhang Lin founded shaoyang Theta Biological Thechnology Co.,Ltd.
Business Scope:
Pharmaceutical intermediate
Biotechology development
Fine organic chemistry
Biopharmaceutical
 
History of the company 
 
 In 2009,Dr Zhang Lin from Johns Hopkins University founded the theta Biological Laboratory.He is committed to the study of protein assimilation preparations.
 
   
In 2013,Dr Zhang Lin returned to China to work in MSD China,and continued to work on biopharmaceutical research and development.
 
 
   In 2018,Dr Zhang Lin founded shaoyang Theta Biological Thechnology Co.,Ltd.
 
 
 
 
 
Business Scope:
Pharmaceutical intermediate
Biotechology development
Fine organic chemistry
Biopharmaceutical

 

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