API omeprazole pellets powder

Product Name:

Omeprazole

Synonyms:

1h-benzimidazole,5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulf;2-Chloromethyl-3,5-dinmethyl-4-methoxypyridine;5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazol;audazol;aulcer;belmazol;ceprandal;elgam

CAS:

73590-58-6

MF:

C17H19N3O3S

MW:

345.42

Product Categories:

Drug bulk;Active Pharmaceutical Ingredients;Omeprazole;Intermediates & Fine Chemicals;Pharmaceuticals;API's;ATPase;Metabolite Reference Standard;Isotopically Labeled Pharmaceutical Reference Standard;OSMITROL;Other APIs;Digestive System

Mol File:

73590-58-6.mol

Chemical Properties

melting point

156°C

boiling point

599.991 °C at 760 mmHg

density

1.371 g/cm3

flashing ponit

316.663 °C

storage temp.

2-8°C

solubility

H2O: 0.5 mg/mL

stability

Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.

Usage And Synthesis

Chemical Properties

White Crystalline Solid

Usage

Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative

diuretic, sweetener, diagnostic aid

A selective proton pump and CYP inhibitor

Omeprazole Pellets are used in the treatment of Gastroesophageal reflux disease (GERD): A condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus)

Biological Activity

H + ,K + -ATPase inhibitor (IC 50 = 5.8 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.16 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A (K i values are 3.1, 40.1 and 84.4 μ M respectively) and blocks swelling-dependent chloride channels (ICIswell).