146-48-5(Yohimbine)

146-48-5(Yohimbine)

146-48-5(Yohimbine)

Min.Order / FOB Price:Get Latest Price

1 Gram

Negotiable

  • Min.Order :1 Gram
  • Purity: 97%-99.9%
  • Payment Terms : T/T,Other

Keywords

146-48-5 Yohimbine C21H26N2O3

Quick Details

  • Appearance:Brown fine powder
  • Application:An important raw material
  • PackAge:as customer's request
  • ProductionCapacity:500|Metric Ton|Week
  • Storage:According to the requirements
  • Transportation:by sea/air

Superiority:


				

					 

				

					 

				

					 

				

					Coreychem

				

					Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade.

				

					 

				

					 

				

					Innovative

				

					Henan Coreychem is committed to continuously explore new compound synthesis technology in recent years,we were on enzyme catalysis, catalytic metal complexes in the total synthesis was tested and achieved good results: S.lycopersicum (+) - Aszonalenin (+) - Citrinadin B Total Synthesis of ( − )-Brevicompanine B by Ir-Catalyzed Total Synthesis of (+)-Citrinadin B

				

					 

				

					 

				

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					Electronic chemicals

				

					 

				

					Catalyst

				

					Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

					
		

	




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													Coreychem
											

											

												
													Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade.
											

											

												
													
											

										
									

										
							

						
					

						
				
					 
				
					

						
							

								
									 
							

							

								
									Innovative
							

							

								
									Henan Coreychem is committed to continuously explore new compound synthesis technology in recent years,we were on enzyme catalysis, catalytic metal complexes in the total synthesis was tested and achieved good results: S.lycopersicum (+) - Aszonalenin (+) - Citrinadin B Total Synthesis of ( − )-Brevicompanine B by Ir-Catalyzed Total Synthesis of (+)-Citrinadin B
							

							

								
									
							

						
					

						
			

		
	





	
		

			
				 
		

		

			
				
			
		

	




	

		
			

				
					

						
							

								
									
								
									

										
											

												
													Coreychem
											

											

												
													Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade.
											

											

												
													
											

										
									

										
							

						
					

						
				
					 
				
					

						
							

								
									 
							

							

								
									Innovative
							

							

								
									Henan Coreychem is committed to continuously explore new compound synthesis technology in recent years,we were on enzyme catalysis, catalytic metal complexes in the total synthesis was tested and achieved good results: S.lycopersicum (+) - Aszonalenin (+) - Citrinadin B Total Synthesis of ( − )-Brevicompanine B by Ir-Catalyzed Total Synthesis of (+)-Citrinadin B
							

							

								
									
							

						
					

						
			

		
	





	
		

			
				 
		

		

			
				
			
		

	




	 



                        

                                            

                            
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					Yohimbine Basic information
			

		
	

	

		
			

				
					Product Name:
				
					Yohimbine
			

			

				
					Synonyms:
				
					D-YOHIMBINE;17alpha-hydroxy-yohimban-16alpha-carboxylic acid methyl ester;ALPHA-YOHIMBIN;RAUBASIN;yohimbine;YOHIMBINE, C-;17alpha-Hydroxyyohimban-16alpha-carboxylic acid;17-alpha-hydroxy-yohimban-16-alpha-carboxylicacimethylester
			

			

				
					CAS:
				
					146-48-5
			

			

				
					MF:
				
					C21H26N2O3
			

			

				
					MW:
				
					354.45
			

			

				
					EINECS:
				
					205-672-0
			

			

				
					Product Categories:
				
					-;Adrenoceptor;API;Plant extracts
			

			

				
					Mol File:
				
					146-48-5.mol
			

			

				
					Yohimbine Structure
			

		
	





	

		
			

				
					 
			

			

				
					Yohimbine Chemical Properties
			

		
	

	

		
			

				
					Melting point 
				
					231-233 °C(lit.)
			

			

				
					alpha 
				
					D20 +50.9 to +62.2° (ethanol); D20 +108° (pyridine); 20546 +129° (c = 0.5 in pyridine)
			

			

				
					Boiling point 
				
					487.66°C (rough estimate)
			

			

				
					density 
				
					1.1640 (rough estimate)
			

			

				
					refractive index 
				
					1.6500 (estimate)
			

			

				
					storage temp. 
				
					Store at RT
			

			

				
					CAS DataBase Reference
				
					146-48-5(CAS DataBase Reference)
			

			

				
					NIST Chemistry Reference
				
					Yohimbine(146-48-5)
			

		
	





	

		
			

				
					 
			

			

				
					Safety Information
			

		
	

	

		
			

				
					Hazard Codes 
				
					T
			

			

				
					Risk Statements 
				
					23/24/25-39
			

			

				
					Safety Statements 
				
					27-36/37/39-45
			

			

				
					RIDADR 
				
					1544
			

			

				
					RTECS 
				
					ZG1000000
			

			

				
					HazardClass 
				
					6.1(a)
			

			

				
					PackingGroup 
				
					II
			

		
	





	

		
			

				
					
			

			

				
					MSDS Information
			

		
	

	

		 





	

		
			

				
					 
			

			

				
					Yohimbine Usage And Synthesis
			

		
	

	

		
			

				
					Chemical Properties
				
					Glistening, needle-like alkaloid, soluble in alcohol and ether, very slightly soluble in water.
			

			

				
					Uses
				
					sexual dysfunction
			

			

				
					Uses
				
					Yohimbine occurs in Corinanthe johimbeK. and Rubiaceae trees. It is also foundin the roots of Rauwolfia serpentina L.and Apocyanaceae. Its derivatives areused therapeutically as adrenergic blockingagents.
			

			

				
					Definition
				
					ChEBI: An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.
			

			

				
					General Description
				
					Yohimbine (Yocon)is a competitive and selective 2-blocker. The compound isan indolealkylamine alkaloid and is found in the bark of thetree Pausinystalia yohimbe and in Rauwolfia root.
			

			

				
					Health Hazard
				
					Pharmacologically, yohimbine is an adrenergic blocking agent. It exhibits hypotensive and cardiostimulant activities. Poisoningfrom excessive doses may become severe,causing convulsions and respiratory failure

					LD50 value, intraperitoneal (mice): 16 mg/kg

					LD50 value, oral (mice): 37 mg/kg.		
			

			

				
					Biological Activity
				
					α 2 -adrenoceptor antagonist (pK i values are 8.52, 8.00 and 9.17 for human a 2A , a 2B and a 2C receptors respectively).
			

			

				
					Clinical Use
				
					Yohimbine increases heart rate and blood pressure as aresult of its blockade of 2-receptors in the CNS. It has beenused experimentally to treat male erectile impotence.
			

			

				
					Purification Methods
				
					Crystallise the alkaloid from EtOH, and dry it in a vacuum to remove EtOH of crystallisation. [Van Tamelen et al. J Am Chem Soc 91 7315 1969, Stork
			

		
	





	 



                        

                

                

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