Methyl 3,4,5-trimethoxybenzoate

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0 Metric Ton	Negotiable

0 Metric Ton

Negotiable

Min.Order :0 Metric Ton
Purity: 98%

Keywords

NSC 16955 3,4,5 -Trimethoxy Benioate METHYL 3,4,5-TRIMETHOXYB

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Application:used as a pharmaceutical intermediate and is the main raw material of the anti-anxiety drug trimetine and the gastrointestinal drug trimebutine maleate.
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By the gallic acid and dimethyl sulfate methylation reaction. Water, gallic acid, dimethyl sulfate to join reaction pot, add sodium hydroxide solution under 15 to 35 ℃, 40 ℃ stir around half an hour. Add the second batch of dimethyl sulfate, around 40 ℃ to add sodium hydroxide solution pH of 8 to 9. Continue after 1 h of reaction, cooling, filtering, washing, drying, preparation base benzoic acid methyl ester, yield of above 90%. The methylation, the esterification reaction, also can use tetrabutyl ammonium bromide as phase transfer catalyst, in the water and chloroform. The goods tannic acid can also be used as raw material, or by three, four, five - preparation base benzoic acid and methanol esterification to making.

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