LY2835219;Bemaciclib; Abemaciclib / LIDE PHARMA --Factory supply/ Best price

Details:

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China.  Our core business line covers APIs, Intermediates, Herb extract, etc.

We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs) and rare chemicals. 

We also accept custom synthesis project and contract research services.

R&D strength:

We have well equipped chemicals and instrumental laboratories with modern instruments such as HPLC,GC,IR,UV,NMR,LC-MS etc.

At present, we are selling it with good discount for immediate delivery !  

Product name: LY2835219; Abemaciclib; Bemaciclib

CAS No.: 1231929-97-7

MF: C27H32F2N8

MW:  506.5933864

Appearance: White powder

Standard: 99%min.

Lead time: Immediate delivery

Packing: 1kg/Al-foiled bag

Payment: T/T advance, , L/C Sight

Sample: Available 

COA/MSDS: Please contact us to desire

Usage:  This oral cell cycle inhibitor (FWfree-base = 506.61 g/mol; FWmesylate-salt = 602.70 g/mol; CAS 1231930-82-7 (mesylate salt) ), also known as LY2835219 and N-[5-[ (4-ethyl-1-piperazinyl) methyl]-2-pyridinyl]-5- fluoro-4-[4-fluoro-2-methyl-1- (1-methylethyl) -1H-benzimidazol-6-yl]-2- pyrimidinamine, targets the cyclin-dependent kinase CDK4, or cyclin D1 (IC50 = 2 nM) and CDK6, or cyclin D3 (IC50 = 6 nM), inhibiting retinoblastoma (Rb) protein phosphorylation in early G1, thereby arresting the cell cycle in the G1, suppressing DNA synthesis, and inhibiting cancer cell growth. LY2835219 inhibits activation of AKT and ERK, but not mTOR.

Transportation: By Air, By Sea, By courier (DHL/FedEx/EMS)

Storage: In well-closed container, protected from light and in cool & dry place.