PF-06463922 Loratinib

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price: USD 200.0000

1 Kilogram

FOB Price: USD 200.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,

Keywords

PF-06463922 99% PF-06463922 Loratinib

Quick Details

Appearance:white powder
Application:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and
PackAge:As customer request
ProductionCapacity:20|Metric Ton|Month
Storage:Dry, sealed and protected from light
Transportation:By Sea/Air/DHL/TNT/UPS

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Weifang Ruze New Material Production Introduction

PF-06463922

[Product Name]:PF-06463922

[Synonyms]:Loratinib (PF-06463922);Lauratinib

[CAS]:1454846-35-5

[MF]:C21H19FN6O2

[MW]:406.4129632

[EINECS]:813-704-5

[Assay]:99%

[Package]:as customer request

[Customer Request]: Available

[Usage]:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]

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