CasNo.936623-90-4,LCZ-696,(936623-90-4) Suppliers

1 Kilogram	FOB Price:USD 2.0000 -3.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T

Keywords

Entresto Valsartan sacubitril

Quick Details

Appearance:White crystalline powder
Application:LCZ696 is used for the treatment of heart failure , LCZ696 is believed to be able to reduce the pressure of heart failure, and promote heart muscle ability
PackAge:In small aluminum foil bag or 1kg-10kg Tin
ProductionCapacity:100|Metric Ton|Week
Storage:Store In Dry, Cool And Ventilated Place
Transportation:By Sea Or By Air

Superiority:

LCZ-696

[Chemical Name]:	Valsartan/sacubitril; LCZ-696; LCZ 696
[Synonyms ]:	Entresto; L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5); trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3-methyl-2-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4-ylmethyl}amino)butyrate] hemipentahydrate; trisodium 3-((1S,3R)-1-(biphenyl-4-ylmethyl)-3-(ethoxycarbonyl)butylcarbamoyl)propionate (S)-3-methyl-2-(pentanoyl-(2-(tetrazol-1-at-5-yl)biphenyl-4'-ylmethyl)amino)butyrate hemipentahydrate
[CAS No.]:	936623-90-4
[Structure Formula]:
[Molecular Formula]:	C48H55N6Na3O8 / C48H55N6O8(-3)
[Molecular Weight]:	843.99
[Solubility]:	in DMSO > 10 mM
[Purity ( Assay ) ]:	99.0% min
[Biological activity ]:	LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). IC50 value: Target: AT II receptor; neprilysin Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours) . LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms .
[Usage/Application]:	LCZ696 is used for the treatment of heart failure , LCZ696 is believed to be able to reduce the pressure of heart failure, and promote heart muscle ability
[Packing]:	In small aluminum foil bag or 1kg-10kg Tin

Our Server

1. Competitive offers with standard high quality or customize

2. Available customizing blending of above 2 single products

3. Prompt delivery within 2-3 weeks(1 weeks is available for ready stock)

4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 years

5. Respond to inquires within 1 hour and 24hours' online service

6. Free sample and correct shipping documents dispatched according to regulations of different countries

7. Advise price trend accurately and help clients to make order decision

8. Weekly update offers provided to every potential client

Details:

Founded in 2008, East Chemsources Limited is a professional manufacturer of supplier in food and pharmaceutical field in China.

Through more than four years development, QINGDAO EAST CHEMSOURCES TRADE CO.,LTD,there is new branch office Qingdao East Chemsources Limited,our company has developed from single product at first to providing solution to finished products now, is committed to providing solutions for success and growth through long term relationships.

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Currently, our products have been exported to more than 50 countries all over the world. Our service is accomplished by providing good quality solution that matches the specifications of our clients at competitive price. Our products will derive from trusted sources and arrive to our clients in time and well arranged manner, be creating the greatest benefits for our customers.

Whether your project is large or small, whether it needs one, several or all of our disciplines you will find our level of dedication to a quality result to be the same. We are looking forward to your sincere cooperation and participation.