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Temsirolimus 162635-04-3 CCI-779
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Product Name |
Temsirolimus |
CAS |
162635-04-3 |
Molecular Formula |
C56H87NO16 |
Molecular Weight |
1030.29 |
Density |
1.2g/cm3 |
Melting Point |
99-101°C |
Boiling Point |
1048.4°C at 760mmHg |
Flash Point |
587.8 °C |
Storage |
−20°C |
Appearance |
White powder |
Solubility |
Soluble in chloroform, methanol. |
Application:
Temsirolimus (CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
Temsirolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a protected bis(dihydromethyl)propionic acid, followed by deprotection. Like all tacrolimus analogues, temsirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins
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