CasNo.137071-32-0,Factory Supply Top Quality Topical Immunomodulators Raw Powder CAS 137071-32-0 Pimecrolimus,(137071-32-0) Suppliers

1 Gram	FOB Price:USD 150.0000 -200.0000

Min.Order :1 Gram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

Pimecrolimus CAS 137071-32-0 Topical Immunomodulators Pimecrolimus

Quick Details

Appearance:White powder
Application:Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis (eczema).
PackAge:Aluminum foil bag,fluorinated bottles,carboard drums or as your special request.
ProductionCapacity:10|Metric Ton|Month
Storage:Store in cool & dry place. Keep away from strong light Shelf Life2 years when properly stored.
Transportation:1) Door to Door Service by DHL/FEDEX/EMS/TNT for package under 45kgs 2) Port to Port Service by Air for package more than 45kgs 3) Port to Port Service by Sea for package more than 500kgs

Superiority:

1) Provide costomers with "one-stop"packaging service,from research,development,production,export and so on.
2) We have our own R&D and production base,equipped with advanced production equipment and precision testing the Unitef States Pharmacopoeia(USP),the Britis Pharmacopoeia(EP) and other international advanced standards.All products are through the KOSGER,HALAL certification,the ISO quality management system certification and the HACCP certification.
3) More than 12 years of export experience.
4)Competitive price in China market.

Details:

Product Name	Pimecrolimus
Synonyms	ASM 981 Picrolimus
CAS	137071-32-0
Molecular Formula	C₄₃H₆₈ClNO₁₁
Molecular Weight	810.459
Density	1.19
Boiling Point	866.1°C at 760 mmHg
Flash Point	477.6 °C
Storage	−20°C
Refractive Index	1.543
Vapour Pressure	5.44E-35mmHg at 25°C
Appearance	White powder

Description:

Pimecrolimus is a topical immunomodulators and is a kind of semi-synthetic products of the Streptomyces-produced ascomycin. It has a greater lipophilicity than tacrolimus with a stronger affinity with the skin. It can effectively and safely control the signs and symptoms of facial seborrheic dermatitis and can quickly relieve the itching symptoms of patients with dermatitis and eczema as well as reduce the lesion area, clear atopic dermatitis (eczema) sign. Therefore, it is an effective treatment method for the treatment of atopic dermatitis (eczema) for both early remission purpose and long-term control purpose.
Seborrheic dermatitis is the body's immune inflammatory response to lipophilic Malassezia. Both the humoral and cellular immunity participate in the sickening process. Pimecrolimus can selectively inhibit the activation of T cell through inhibiting the activity of the calcium-dependent nerve transcription proteins which is indispensible for the activation of T cells and prevent the release of cytokines and pro-inflammatory mediator, and further exhibiting strong anti-inflammatory activity. These results suggest that the mechanism of pimecrolimus for treatment of seborrheic dermatitis comes from its anti-inflammatory effect and immune regulation. Currently there have been no reports regarding on its direct participation of antifungal activity. But in recent years, there have been reports finding that tacrolimus (a kind of immunomodulatory agents with similar chemical structure and mechanisms as pimecrolimus) have some anti-Malassezia activity.

Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins.

FAQ

Q1. Are you a manufacturer

Answer: Yes, we have our own factory and lab.

Q2. Do you have GMP or DMF

Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.

Q3. What information should I let you know if I want to get a quotation

Answer: -Quality you require, eg. Assay, Purity, or single impurity

-Quantity you need

-Standard you want, such as USP, EP, JP etc.

Q4. How to make the payment

Answer: Escrow and T/T in advance are highly recommended. We can accept , Money Gram and Paypal as well.

Q5. When will you deliver the goods

Answer: For sample, in about 2 working days after payment; for larger orders (more than 1kg), in about 5 working days after payment.

Q6. How will you deliver the goods

Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping.

You also can choose your own shipping forwarder.

Q7. When will we receive the goods

Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.

Q8. What if we find your products unsatisfied

Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.