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1 Gram |
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Paclitaxel Taxol Paclitaxel Price
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Product Name |
Paclitaxel |
Synonyms |
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv Taxal |
CAS |
33069-62-4 |
Molecular Formula |
C47H51NO14 |
Molecular Weight |
853.91 |
Density |
1.39 |
Melting Point |
213-216°C |
Boiling Point |
957.115 °C at 760 mmHg |
Storage |
2-8°C |
Refractive Index |
-49 ° (C=1, MeOH) |
Solubility |
methanol: 50 mg/mL, clear, colorless |
Appearance |
White powder |
Description:
Paclitaxel is a monomer diterpenoid compound extracted from Natural Plant Paclitaxel bark, is a kind of complex secondary metabolites, is currently understood only a drug can promote microtubule polymerization and stability of microtubules have been aggregated. Isotope tracing showed that paclitaxel was bound only to polymerized microtubules, not to the polymerized tubulin two. Cell contact paclitaxel after the accumulation of a large number of microtubules in cells, which interfere with microtubule accumulation of various cellular functions, especially the cell division stop in mitosis, blocking the normal cell division.
Application:
Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
Function:
1.Paclitaxel is mainly applied to ovarian and breast cancer, lung cancer, colorectal cancer,melanoma, head and neck cancer, lymphoma, and it also have a certain effect on brain tumors.
2.It is stability drugs that can promote microtubule polymerization and microtubule polymerization.
3.There will be accumulated a large number of microtubules in the cells after exposure to paclitaxel, the accumulation of microtubules interferes with cell functions, in particular, stoped cell division in mitosis, blocking normal cell division.
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