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Entecavir Entecavir Price 142217-69-4
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Product Name |
Entecavir |
CAS |
142217-69-4 |
Molecular Formula |
C12H15N5O3 |
Molecular Weight |
277.28 |
Density |
1.81g/cm3 |
Melting Point |
249-252°C |
Boiling Point |
734.2°C at 760 mmHg |
Flash Point |
397.9°C |
Refractive Index |
1.837 |
Storage |
-20°C Freezer |
Appearance |
White powder |
Entecavir is a new generation of guanine nucleoside analogues oral medicine for treatment of hepatitis B virus infection in, mainly for the treatment of adult patients with viral replication activity and serum transaminase continued to increase, or liver tissue for pathological activity of chronic hepatitis B, is currently down virus the fastest and the most powerful, the mutation rate lowest nucleoside analogues.
Data show that different in patients with chronic hepatitis B, including nucleoside naive and nucleoside treated and liver cirrhosis patients, using well entecavir tablets in the treatment can control the disease rapidly and easily reach the treatment of reality end, namely the hepatitis B virus unmeasured; through adherence to treatment, a considerable portion of patients can be arrived at the end of treatment satisfaction, namely e antigen serology conversion, some patients can even reach the ideal for the treatment of end, namely surface antigen negative.
Uses:
Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease with elevations in liver enzymes. It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV. Entecavir is weakly active against HIV, but is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV.
The efficacy of entecavir has been studied in several randomized, double-blind, multicentre trials. Entecavir by mouth is effective and generally well tolerated treatment.
Pregnancy and breastfeeding
It is considered pregnancy category C in the United States, and currently no adequate and well-controlled studies exist in pregnant women.
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