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Entecavir hydrate Entecavir Monohydrate 209216-23-9
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Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir hydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the vira.
Product Name |
Entecavir hydrate |
CAS |
209216-23-9 |
Molecular Formula |
C12H17N5O4 |
Molecular Weight |
295.29 |
Density |
1.81g/cm3 |
Melting Point |
>220°C |
Boiling Point |
661.4°C at 760 mmHg |
Flash Point |
353.8°C |
Vapour Pressure |
2.15E-18mmHg at 25°C |
Refractive Index |
1.837 |
Appearance |
White powder |
Entecavir Hydrate is a new kind of cyclopentyl acyl guanosine anti-hepatitis b virus drugs with its pharmacological effects similar as entecavir. It is clinically applied to the treatment of adult chronic hepatitis b in which there is active viral replication, increased serum transaminase ALT or active lesions showed from liver histology.
Entecavir Monohydrate is a kind of analogues of guanine nucleoside which has inhibitory on the polymerase of hepatitis b virus (HBV). It can become active triphosphate salts through phosphorylation. The triphosphate salt has a half-life of 15 hours inside a cell. Through completion with the natural substrates of HBV polymerase, guanine nucleoside triphosphate, entecavir triphosphate can suppress all the three types of activities of the virus polymerase (reverse transcriptase):
(1) The initiation of HBV polymerase.
(2) The formation of the negative chain of reverse transcription of the pre-genome.
(3) The synthesis of HBVDNA positive chain.
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