CasNo.4759-48-2,low price Isotretinoin with high quality,(4759-48-2) Suppliers

1 Kilogram	FOB Price:USD 1.0000 -5.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

4759-48-2 Isotretinoin RETINOIC ACID, 13-CIS-

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Appearance:White Crystalline Powder
Application:Pharma. APIS
PackAge: Customized
ProductionCapacity:100|Kilogram|Month
Storage:Cool and dry place
Transportation:by sea, by air

Superiority:

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

Our R&D center building area is 811 square meters, with 3 contributing proffesor of technical advisor, 4 Dr., 10 masters, and 28 research staff. Our level of chemical synthesis is known to the industry. So we have accumulated rich experience in synthetic methods design and exploring the synthesis of new technology. Not only we are good in heterocyclic chemistry, chiral chemistry (asymmetric synthesis and enzyme reactions), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry, including nucleosides, nucleotides, sugar chemistry, peptide chemistry. R & D center has many sets of 10 liters, 20 liters, 50 liters, 100L multifunction high and low pressure reaction still, rotary evaporator, anhydrous anaerobic reaction devices, hydrogenation equipment, cryogenic process (-120 degrees) equipment, to complete mg level custom synthesis and kg level process development experiments. The Existing 600M NMR, LCMS, Fourier Infrared Spectrometer, liquid chromatography, differentialscanning calorimetry, and other advanced detection equipment areto ensure quality and efficient completion of R&D projects. So far our completed custom synthesis products is more than 5300 species, where dozens of them are non-CAS declaration products, almost including all types of organic reactions.

At present, in addition to our headquarters in Zhengzhou, we also have another product base in Jun County, Henan Province. This base is the attracting investment of science and technology project of Jun County govenment’s, which covers 6529 square meters. In addition to bear our own company’s 1000L-5000L pilot task, also bear the function of Henan pilot incubation service platform, In order to improve Henan and surroundings’ synthetic reaction pilot service ability and the key technology development capabilities. Base with three GMP standards workshop, a testing center, one test center,one experiment center and associatd supporting facilities, can carry out oxidation, hydrogenation (70 kg pressure), halogenated, acieration, etherification, condensation, cyclization, formatting, ammoniated, diazotization andpilot service such as azide reactions etc. In the future we will work hard to make it become the most complete production system in central China and even the whole country, the highest technical level, the strongest talent team, the most popular service scope of pilot incubation service platform.

Henan Coreychem co., LTD. is committed to provide cost effective chemical service to the global fine chemical industry product development agencies; we adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, let our customers faster, better get ideal and thoughtful service.

Details:

Isotretinoin Basic information

Pharmacological effects Physical and Chemical Properties Pharmacokinetics Indications Clinical application Toxicity Drug Interactions Contraindications Side effects Chemical Properties Uses Production methods

Product Name:	Isotretinoin
Synonyms:	Tretinoin Impurity 1（Tretinoin EP Impurity A）;RETINOIC ACID, 13-CIS-;3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid;3,7-DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-2Z,4E,6E,8E-NONATETRANENOIC ACID;13-CIS-RETINOIC ACID;13-cis-vitamin a acid;(L)-ISOTRETINOIN;ISOTRETINOIN
CAS:	4759-48-2
MF:	C20H28O2
MW:	300.44
EINECS:	225-296-0
Product Categories:	Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;-;API;BUSPAR;Other APIs;intermediates
Mol File:	4759-48-2.mol

Isotretinoin Chemical Properties

Melting point	172-175 °C(lit.)
Boiling point	381.66°C (rough estimate)
density	1.0597 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	−20°C
solubility	Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). It is sensitive to air, heat and light, especially in solution. Carry out all operations as rapidly as possible and avoid exposure to actinic light; use freshly prepared solutions.
form	Fine Crystalline Powder
color	Yellow-orange to orange
Water Solubility	insoluble
λmax	354nm(EtOH)(lit.)
Merck	14,5228
Stability:	Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	4759-48-2(CAS DataBase Reference)
EPA Substance Registry System	Retinoic acid, 13-cis-(4759-48-2)

Safety Information

Hazard Codes	T
Risk Statements	61-36/37/38-20/21/22
Safety Statements	53-26-36/37/39-45-37/39
WGK Germany	3
RTECS	VH6440000
TSCA	Yes
HS Code	29362100
Hazardous Substances Data	4759-48-2(Hazardous Substances Data)
Toxicity	LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm)

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