CasNo.104594-70-9,Phenethyl caffeate competitive product,(104594-70-9) Suppliers

1 Kilogram	FOB Price: USD 0.1000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T,Other

Keywords

reliable quality and fast delivery Advanced technology and favourable payment terms good business manners

Quick Details

Appearance:according to email quotation
Application:pharmaceutical raw materials
PackAge:foil aluminium bag/vacuum packing
ProductionCapacity:100|Kilogram|Week
Storage:Keep in dry and cool condition
Transportation:by air or by sea

Superiority:

Coreychem competetive product

High quality and favourable price

Perfect logistics system

Advanced and completed testing facilities

High Cost-Effective and stable supplying

Coreychem focus on high complex new type intermediates and fine chemical custom synthesis,scale-up production and rare chemicals trade.Product category including Intermediates&API,Catalyst and Electronic Chemicals.Covering 811 square meters R&D center,with 45 person R&D team,our synthesis level is well-known to the industry,which are exported to France,Poland,Czech,Ukraine,Spain,Switzerland,etc...

Details:

Product Name:	Phenethyl caffeate
Synonyms:	Caffeic Acid 2-Phenylethyl Ester;CAFFEIC ACID PHENETHYLESTER (CAPE);CAPE,PhenethylCaffeate;CAFFEIC ACID PHENETHYL ESTER(CAPE)(P);KAFFEESUREPHENYLETHYLESTER;CAFFEICACIDPHENYLETHERESTER;3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester;Cafestol Acid Phenethyl Ester
CAS:	104594-70-9
MF:	C17H16O4
MW:	284.31
EINECS:	627-151-0
Product Categories:	Miscellaneous Natural Products;Inhibitors;Tyrosine Kinase Inhibitors;Cytokine signaling;HIV/AIDS/Related Products;Apoptosis Inducers;-
Mol File:	104594-70-9.mol

Phenethyl caffeate Chemical Properties

Melting point	127-129℃
storage temp.	Store at 0°C
solubility	Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.
form	White to off-white solid
color	off-white
λmax	323nm(lit.)
Sensitive	Light Sensitive
InChIKey	SWUARLUWKZWEBQ-VQHVLOKHSA-N
CAS DataBase Reference	104594-70-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-38-37-36
Safety Statements	26-36
WGK Germany	3
RTECS	UD3334375
HS Code	29182900

MSDS Information

Phenethyl caffeate Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	antineoplastic, antiinflammatory, immunomodulator, NFkB blocker
Uses	Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.
Biological Activity	Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
Contact allergens	Capee is one of the allergens of propolis (bee glue). It is also contained in poplar bud secretions.
Anticancer Research	Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).