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nintedanib 656247-17-5 nintedanib powder
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Introduction
Product Name |
Nintedanib (Ofev) |
Other Name |
3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]- |
Molecular Formula |
C31H33N5O4.C2H6O3S |
Molecular Weight |
649.76 |
CAS No. |
656247-18-6 |
Appearance |
White Powder |
Key words |
Treatment of idiopathic pulmonary fibrosis |
Nintedanib is the first FDA-approved drug for the management of idiopathic pulmonary fibrosis (IPF), a rare but often fatal lung disease. Nintedanib is believed to exert its mechanism of action by inhibiting multiple receptor tyrosine kinases, including those that have been implicated in the pathogenesis of IPF (i.e., fibroblast growth factor receptor, platelet-derived growth factor receptor, and vascular endothelial growth factor receptor). Nintedanib also inhibits nonreceptor tyrosine kinases, although the contribution of this inhibition in the efficacy of the drug is unknown.
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