Paracetamol 103-90-2 Paracetamol
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Pharm grade paracetamol powder Acetaminophen tablets
CAS 103-90-2
Paracetamol powder in india (Acetamidophenol )
CAS No.:103-90-2
Moleacular Formula: C8H9NO2
Molecular Weight: 151.16
EINECS: 203-157-5
Purity: 99.5%~101.0%
Certificate of Analysis, USP30/BP98
Appearance: A white to pale yellow crystalline powder. Odorless and a little bitter.
Use: It is a broad-spectrum antibiotic of high efficacy.
Paracetamol is approved for reducing fever in people of all ages.
Paracetamol is used for the relief of pains associated with many parts of the body. It has analgesic properties comparable to those of rests, while its anti inflammatory effects are weaker
It is better tolerated than rests in patients in whom excessive gastric acid secretion or prolongation of bleeding time may be a concern.
Paracetamol facilitate the formation of thrombin so as to speedup of maintain the normal concretion time of blood.As well as it facilitate the formation. Paracetamol is also diuretic and strengthen liver’s detoxification ability. Deficiency of VK3 will lead to longer concretion time of blood or to bleeding nonstop. That meens even very small wounds may lead to the breach of blood vessels. Resulting in extensive observable under-skin bleeding and bleeding fo other apparatuses or organs sush as: muscles,brain,stomach,intestines,abdomen,urinary systerm,genital system and so on. More seriously. Paracetamol may lead to hematuria and anaemia,even death.
Function:
1.Paracetamol is the most commonly used non-anti-inflammatory antipyretic analgesics, antipyretic effect and rests similar analgesic effect is weak, no anti-inflammatory anti-rheumatic effects, acetanilide drugs is the best varieties. Particularly suitable for patients who can not use carboxylic acids. For cold, toothache embolism. Acetaminophen is also an intermediate for organic synthesis, hydrogen peroxide stabilizer, and photographic chemicals.
2.Paracetamol for antipyretic, analgesic, anti-rheumatic drugs
3.Paracetamol for organic synthesis intermediates, hydrogen peroxide stabilizer, photographic chemicals, non-anti-inflammatory antipyretic analgesics.
COA for Paracetamol
Tests |
Standards |
Results |
|
Appearance |
White or almost white ,crystalline powder. |
White,crystalline powder. |
|
Identification |
A:IR absorption |
Complies |
Complies |
B:UV absorption |
Complies |
Complies |
|
C:TLC |
Complies |
Complies |
|
Melting point |
168~172°C |
169.0~170.9°C |
|
Water |
Not more than0.5% |
0.08% |
|
Related substance |
ImpurityJ(chloroacetanilide)not more than 10 ppm |
2ppm |
|
Impurity K(4-aminophenol)not more than 50 ppm |
15 ppm |
||
Impurity F(4-nitrophenol)not more than 0.05% |
Not detected |
||
any other impurity not more than 0.05% |
0.01% |
||
Total of other impurities not more than 0.1% |
0.02% |
||
Residue on ignition |
Not more than 0.1% |
0.05% |
|
Chloride |
Not more than 0.014% |
Less than 0.014% |
|
Sulfate |
Not more than 0.02% |
Less than 0.02% |
|
Sulfide |
Conforms |
Conforms |
|
Heavy metals |
Not more than 0.001% |
Less than 0.001% |
|
Free p-aminophenol |
Not more than 0.005% |
Less than 0.005% |
|
Limit of P-chloroacetanilide |
Not more than 0.001% |
Less than 0.001% |
|
Readily carbonizable substances |
Conforms |
Conforms |
|
Residual solvents |
Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% |
0.08% |
|
Assay(anhydrous basis) |
99.0~101.0% |
99.6% |
|
Conclusion: Complies with USP34/ BP2011 |
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