97-77-8 DisulfiramCAS NO.: 97-77-8

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1 Gram	FOB Price:USD 4.0000 -5.0000

1 Gram

FOB Price:USD 4.0000 -5.0000

Disulfiram manufacturer Disulfiram high purity Disulfiram

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Chemical Properties	yellow-white crystals or grey powder
Uses	It is used as rubber accelerator; vulcanizer; seed disinfectant; fungicide; alcohol deterrent.
Uses	Alcohol deterrent;Dopamine beta-hydroxylase inhibitor
Uses	For the treatment and management of chronic alcoholism
Uses	Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence. It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells. Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.
Definition	ChEBI: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Brand name	Antabuse (Odyssey) .