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Glutaraldehyde manufacturer Glutaraldehyde high purity Glutaraldehyde
Chemical Properties | Glutaraldehyde is a colorless liquid with a pungent odor, which readily changes to a glossy polymer. The Odor Threshold is 0.04 ppm (NY) and 0.2 ppm (NJ). |
Uses | glutaral (glutardialdehyde) is a broad-spectrum preservative that can cause skin irritation. This is an amino acid occurring in green sugar beets. |
Uses | Recommended for techniques demanding high purity. |
Uses | Contains variable amounts of polymer.1 |
Uses | Cross-linking agent for gelatin,1,2 poly(vinyl alcohol),3 and polyheptapeptides.4 |
Uses | Glutaraldehyde is used to disinfect medical and dental equipment. Glutaraldehyde is also used for industrial water treatment and as a preservative. |
Uses | Glutaraldehyde is used as a cold sterilizingdisinfectant, as fixatives for tissues, in tanning,and in cross-linking proteins. |
Definition | ChEBI: A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5. |
General Description | Light yellow liquid. Mixes with water. |
Air & Water Reactions | Polymerizes in the presence of water. |
Reactivity Profile | GLUTARALDEHYDE may discolor on exposure to air. Pentanedial polymerizes on heating. Pentanedial is incompatible with strong oxidizing agents. Pentanedial polymerizes in the presence of water. |
Health Hazard | Contact with liquid causes severe irritation of eyes and irritation of skin. Chemical readily penetrates skin in harmful amounts. Ingestion causes irritation of mouth and stomach. |
Health Hazard | Glutaraldehyde is a strong irritant to the nose,eyes, and skin. In rabbits, 250 μg and 500 mg in 24 hours produced severe irritation in theeyes and skin, respectively. The corrosiveeffect on human skin of 6 mg over 3 dayswas severe. However, the acute toxicity ofglutaraldehyde by the oral and dermal routesis low to mild. Ohsumi and Kuroki (1988)determined that the symptoms of acute toxicityof this compound were less severethan those of formaldehyde. But the restraintof growth was more pronounced in micetreated with glutaraldehyde. An oral LD50value of 1300 mg/kg was reported for mice.Inhalation of this compound can cause upperrespiratory tract irritation, headache, and nervousness.Mice exposed at 33 ppm showedsymptoms of hepatitis. |
Fire Hazard | Literature sources indicate that Pentanedial is nonflammable. |
Contact allergens | Glutaraldehyde is a well-know sensitizer in cleaners and health workers. It can also be found in X-ray developers or in cosmetics. |
Safety Profile | Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by inhalation, skin contact, and subcutaneous routes. Experimental teratogenic and reproductive effects. A severe eye and human skin irritant. Mutation data reported. When heated to decomp osition it emits acrid smoke and irritating fumes. See also ALDEHYDES. |
Potential Exposure | Glutaraldehyde is used in leather tanning; in embalming fluids; as a germicide; as a cross-linking agent for protein and polyhydroxy materi als; as a fixative for tissues; and as an intermediate. Buffered solutions are used as antimicrobial agents in hospitals. |
Shipping | UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. |
Purification Methods | Likely impurities are oxidation products-acids, semialdehydes and polymers. It can be purified by repeated washing with activated charcoal (Norit) followed by vacuum filtration, using 15-20g charcoal/100mL of glutaraldehyde solution. Distil it at 60-65o/15mm, discarding the first 5-10%, then dilute with an equal volume of freshly distilled water at 70-75o, using magnetic stirring under nitrogen. The solution is stored at low temperature (3-4o), in a tightly stoppered container, and protected from light. Standardise by titration with hydroxylamine. [Anderson J Histochem Cytochem 15 652 1967, Beilstein 1 IV 3659.] |
Incompatibilities | Water contact forms a polymer solution. A strong reducing agent. Incompatible with strong acids; caustics, ammonia, amines, and strong oxidizers. Note: Alkaline solutions of glutaraldehyde (i.e., activated glutar aldehyde) react with alcohol, ketones, amines, hydrazines, and proteins. |
Waste Disposal | Dissolve or mix the material with a combustible solvent and burn in a chemical incinera tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. |
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